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The National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) announces a meeting focusing on protein folding and misfolding, especially within the endoplasmic reticulum. There is extensive new research on this topic and on the mechanisms by which disease-associated proteins aggregate and injure cells. Speakers will address both basic science and clinical issues, and several will discuss new concepts for therapeutics, including the use of small molecules and chaperones to prevent protein misfolding or aggregation, to enhance the removal of toxic protein aggregates, or to block the cellular response to the defective protein.

Plenary talks, selected short talks, and a poster session will provide a forum for interactions among both basic and clinical scientists, as well as established and new investigators in the field.


ORGANIZING COMMITTEE

Jeff Kelly, PhD
The Scripps Research Institute

David Perlmutter, MD
University of Pittsburgh


David Ron, MD
New York University Medical Center


Pam Zeitlin, MD, PhD
Johns Hopkins University


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NIDDK STAFF

Carol Haft, PhD

Chris Ketchum, PhD

Catherine McKeon, PhD

Chris Mullins, PhD

Rebekah Rasooly, PhD


Salvatore Sechi, PhD

At the end of this activity participants will be able to understand how errors in protein folding lead to human disease, and appreciate the potential role for chaperones and other small molecules as therapies for disease caused by misfolding or misprocessing of proteins.

The target audience is primarily physician-researchers involved in treatment of patients with the relevant diseases, and in research related to these diseases.

The NIH/FAES is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.



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National Institute of Diabetes and Digestive and Kidney Diseases
U.S. Department of Health and Human Services National Institute of Diabetes and Digestive and Kidney Diseases