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DAY 1: Tuesday, May 4, 2004
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8:00 AM |
Registration and Continental Breakfast
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8:30 AM |
Opening Remarks
Allen Spiegel, MD
Director, National Institute of Diabetes
and Digestive and Kidney Diseases, National
Institutes of Health
Steve Groft, PharmD
Director, Office of Rare Diseases, National Institutes of Health
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8:40 AM |
Introductory Address
Peter Walter, PhD, University
of California at San Francisco
Signaling from the ER to the Nucleus
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9:15 AM |
SESSION I
The ER as a Site for Protein Folding, Complex Assembly,
and Quality Control for the Secretory Pathway
Chair: Dieter H. Wolf, PhD, Universitaet
Stuttgart
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Hidde Ploegh, PhD, Harvard University
TBD
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Charlie Barlowe, PhD, Dartmouth University
TBD
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Dieter H. Wolf, PhD, Universitaet
Stuttgart
Protein Quality Control in the Endoplasmic
Reticulum and the Ubiquitin-proteasome-chaperone Connection
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Randy Hampton, PhD, University of California, San Diego
Reversible, Small Molecule Regulation of ER
Quality Control
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10:45 AM |
Break
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11:00 AM |
SESSION II
The Unfolded Protein Response: Maintenance of Proper Folding in the ER
Chair: David
Ron, MD, New York University School of Medicine
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Doug Cavener, PhD, Pennsylvania State University
PERKs and the Unfolded Protein
Response
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Linda Hendershot, PhD, St. Jude Children's Research
Hospital
ER Complexes and BIP Regulators
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David Ron, MD, New York University School of Medicine
Translational Control in the Unfolded Protein
Response
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Jeff Brodsky, PhD, University of Pittsburgh
Molecular Chaperone Action and Cellular Responses
During ERAD
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12:30 PM |
Lunch
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2:00 PM |
Keynote Lecture
William E. Balch, PhD, The Scripps Research Institute
Protein Traffic in Conformational Diseases
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2:45 PM |
SESSION III
ER Stress and Mis-folding
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Gert Kreibich, PhD, New York University School of
Medicine
Membrane Protein Assembly and Targeting in the Bladder Epithelium
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Craig B. Thompson, PhD, University of Pennsylvania
Programmed Cell Death Induced by ER Stress
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Sanjay Nigam, MD, University of California, San
Diego
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Invited short presentations selected from abstracts
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5:30 PM |
Poster Session/Reception
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DAY 2: Wednesday, May 5, 2004
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7:30 AM |
Continental Breakfast
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8:00 AM |
Introductory
Address
Jeffrey W. Kelly, PhD, The Scripps Research Institute
An Overview of Misfolding Diseases and Therapeutic Approaches
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8:35 AM |
SESSION IV
Defective Protein Folding and Targeting in Renal
Disease
Chair: Jeffrey W. Kelly, PhD, The Scripps
Research Institute
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Michel Bouvier, PhD, Universite de
Montreal
Pharmacological Chaperones; A Potential
Therapeutic Strategy for Nephrogenic Diabetes Insipidus and Other
Conformational Diseases
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Chris Danpure, PhD, University College London
Primary Hyperoxaluria
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Peter Agre, MD, PhD, Johns Hopkins
University
Aquaporins
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Karl Tryggvason, MD, PhD,
University of Oulu
Folding
and Nephrin
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10:05 AM |
Break
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10:20 AM |
SESSION V
Mis-folding and Disease
Chair: David H. Perlmutter, MD, University
of Pittsburgh School of Medicine
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David H. Perlmutter, MD,
University of Pittsburgh School of Medicine
Alpha
1 Antitrypsin Deficiency: Retention of an Aggregated Protein in ER
Causes Liver Disease
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David Ellison, MD, Oregon Health & Science
University
Misfolding and ER Retention
of Renal NCC in Gitelman’s Syndrome
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Show-Ling
Shyng, PhD, Oregon Health & Science University
Defective Trafficking of K ATP Channels in Congenital Hyperinsulinism
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Invited short presentation selected
from abstracts
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11:50 AM |
Lunch
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1:00 PM |
SESSION VI
Mis-folding and Disease
Chair: David H. Perlmutter, MD, University
of Pittsburgh School of Medicine
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Jean Baum, PhD, Rutgers University
NMR and Folding Disease
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Dr. Laura S. Itzhaki, Hutchison/MRC
Research Centre
The Role of Domain Swapping in Protein
Aggregation
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Mark McNiven, PhD, Mayo Clinic
Dynamin and
Endocytosis in Hepatocytes
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2:10 PM |
Break
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2:25 PM |
SESSION VII
Mis-folding, Disease and Therapeutic Approaches
Chair: Pam Zeitlin, MD, PhD, Johns Hopkins University
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Alan Verkman, MD, PhD, University of
California at San Francisco
Small Molecule Therapy and CF
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P. Michael Conn, PhD, Oregon Health
& Science University
Origami of the GnRH Receptor – A New Therapeutic Approach Unfolding
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Pam Zeitlin MD, PhD, Johns Hopkins
School of Medicine
Pharmacologic Approaches to CFTR
Misfolding
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Bob Desnick, MD, PhD, Mount Sinai School of Medicine
Chaperone-mediated Enzyme Enhancement Therapy
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