p53: a universal sensor of genotoxic stress.
The p53 tumor suppressor gene encodes a nuclear phosphoprotein with
cancer-inhibiting properties. The development of human cancer often involves
inactivation of this suppressor function through various mechanisms, including
gene deletions and point mutations. The p53 protein is a multi-functional
transcription factor involved in the control cell cycle progression, DNA
integrity and apoptosis in cells exposed to DNA-damaging agents. Loss
of p53 activity predisposes cells to the acquisition of oncogenic mutations
and may favor genetic instability. Since the identification of tumor-specific,
missense p53 mutations in 1989, there has been a widespread interest in
the possibility that the localization and the characteristics of these
mutations may reveal clues about the etiology and the molecular pathogenesis
of human cancer (Greenblatt et al., 1994. Cancer Res., 54: 4855-78;
Harris-CC, 1996. Carcinogenesis, 17: 1187-98; Ko-L and Prives-C,
1996. Genes Dev., 10: 1054-72; Levine-AJ, 1997. Cell, 88:
323-331). Point mutations are scattered over more than 250 codons and are
common in many forms of human cancer. In this respect, the p53 gene differs
from other tumor suppressor genes such as Rb, APC and ATM which are
frequently inactivated by deletion or nonsense mutations, and from the
oncogenes of the ras family, which are activated by mutation at a small
number of well-defined codons.
For more information on p53 see the LHC p53 Resources Page
p53 Links
Universal Mutation Database
HotMolecBase: p53 tumor Suppressor Gene
p53 at NCBI
p53 at Bioscience
Evolution of p53
GDB Database: Gene TP53
IARC Database of p53 Mutations
Database of Germline p53 Mutations
p53 and APC Databases by Thierry Soussi
p53 Database at UNC by Neil Cariello
p53 Sequence Map
UMD softwares to query the APC, FBN1, LDLR, p53, VHL, and WT1 databases.
Good resources on p53 structure, function, Expression, Metabolism, and other information.
OMIM entry #191170 for p53 Resources.
The p53 mutation database contains information on all missense mutations and small deletions reported in human p53 reported in peer-reviewed literature.
List of Li-Fraumeni mutations in the p53 gene from Charles University, Prague.
we have devised generic software which allows the entry and analysis of mutations in any gene of interest.
This site contains Databases and software for the analysis of mutations at the transgenic and bacterial lacI gene, human p53 gene, hprt gene, transgenic lacZ gene...
Human p53 gene for transformation related protein p53, Acession #: X54156.
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