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Structural Biology of Membrane Proteins (R01)
Release Date: January 20, 2006
Announcement Number: PA-06-119
Application Receipt Date:
February 1, 2006
June 1, 2006
October 1, 2006
Funding Contact: Randall Stewart, Ph.D.
Program Area: Channels, Synapses and Neural Circuits
Brief Description:
This PA solicits applications to develop research and methods to enhance the rate of membrane protein structure determination
and to determine specific membrane protein structures. Innovative methods for expression, oligomerization, solubilization,
stabilization, purification, characterization, crystallization, isotopic labeling, and structure determination of unique and
biologically significant membrane proteins by x-ray diffraction, nuclear magnetic resonance (NMR), electron microscopic,
mass spectrometry, and other biophysical techniques are encouraged. Projects that will lead in the near term to determining
the structures of biologically important membrane proteins are also encouraged.
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