RNA Brain Maps |
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Launch in standalone player | |
Air date: | Monday, December 17, 2007, 12:00:00 PM |
Category: | Neuroscience |
Runtime: | 75 minutes |
NLM Title: | RNA brain maps [electronic resource] / Robert Darnell. |
Series: | NIH neuroscience seminar series |
Author: | Darnell, Robert. National Institutes of Health (U.S.) |
Publisher: | [Bethesda, Md. : National Institutes of Health, 2007] |
Other Title(s): | NIH neuroscience seminar series |
Abstract: | (CIT): Dr. Darnell will speak about how brain-specific splicing factors interacting with splicing silencer and enhancer elements lead to RNA isoforms in the brain that are different from the corresponding isoforms in other organs. One of these splicing factors, NOVA, has a predilection for regulating the splicing of RNAs that encode proteins acting at the neuronal synapse. Indeed, in the absence of NOVA in knock-out mice, synaptic NOVA targets are changed in sequence though not in level, with the consequence that LTP of slow inhibitory postsynaptic currents is completely and specifically absent. So, don't forget splicing when you think of gene expression! And by the way, because NOVA was discovered as a target of an auto-immune reaction in patients with a particular form of a paraneoplastic neurological syndrome, Dr. Darnell's talk should also be interesting to immunologists and clinicians. NIH Neuroscience Seminar Series. |
Subjects: | Brain--physiology Protein Interaction Mapping Protein Isoforms RNA Splicing Synapses--physiology |
Publication Types: | Government Publications Lectures |
Download: | Download
Video How to download a Videocast |
NLM Classification: | WL 102.8 |
NLM ID: | 101463227 |
CIT File ID: | 14215 |
CIT Live ID: | 6173 |
Permanent link: | http://videocast.nih.gov/launch.asp?14215 |
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Description | Runtime | Description | Runtime | |||
Enhanced Audio Podcast | 1:11:15 | Enhanced Video Podcast | 1:11:15 |