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Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
Gräbner R, Lötzer K, …, Weih F, Habenicht AJ
J Exp Med 2009 Jan 16 206(1):233-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley with Ekaterina Koltsova
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Chronic cannabinoid administration in vivo compromises extinction of fear memory.
Lin HC, Mao SC, Chen PS, Gean PW
Learn Mem 2008 15(12):876-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Pertwee with Maria Grazia Cascio
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

Confirmation
Controversial
Novel Drug Target
Changes of bladder activity and connexin 43-derived gap junctions after partial bladder-outlet obstruction in rats.
Miyazato M, Sugaya K, …, Oshiro Y, Saito S
Int Urol Nephrol 2009 Jan 6 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.
Barrett NA, Maekawa A, …, Austen KF, Kanaoka Y
J Immunol 2009 Jan 15 182(2):1119-28 [abstract on PubMed] [related articles] [order article]
Selected by | Richard L. Stevens
Evaluated 30 Jan 2009

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
Single-RNA counting reveals alternative modes of gene expression in yeast.
Zenklusen D, Larson DR, Singer RH
Nat Struct Mol Biol 2008 Dec 15(12):1263-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Oliver Rando with Marta Radman-Livaja
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
Genome-wide expression patterns and the genetic architecture of a fundamental social trait.
Wang J, Ross KG, Keller L
PLoS Genet 2008 4(7):e1000127 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Promislow with Dale Hoyt
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function.
Xu R, Nelson CM, …, Vonderhaar BK, Bissell MJ
J Cell Biol 2009 Jan 12 184(1):57-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Streuli
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.
Fu NY, Sukumaran SK, Kerk SY, Yu VC
Mol Cell 2009 Jan 16 33(1):15-29 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Colman with W. Douglas Fairlie
Evaluated 30 Jan 2009

Exceptional
F1000 Factor 9.0

Confirmation
Hypothesis
Climate change and unequal phenological changes across four trophic levels: constraints or adaptations?
Both C, van Asch M, …, van den Burg AB, Visser ME
J Anim Ecol 2009 Jan 78(1):73-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Oswald Schmitz
Evaluated 30 Jan 2009

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Role of dorsomedial hypothalamic neuropeptide Y in modulating food intake and energy balance.
Yang L, Scott KA, …, Moran TH, Bi S
J Neurosci 2009 Jan 7 29(1):179-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Julian Mercer
Evaluated 30 Jan 2009


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