Hilton Washington DC/Rockville Executive Meeting Center
Rockville, Maryland
October 15–17 2008
Wednesday, October 15, 2008 | ||
5:00–6:00 p.m. | Registration | |
6:00–10:00 p.m. | Dinner and Opening Session | |
Plenary Introduction | ||
7:30–8:15 p.m. | Pathogenic Mechanisms of Alzheimer’s Dementia Lennart Mucke |
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8:15–9:00 p.m. | Mechanisms Linking Alzheimer’s Dementia and Epilepsy Jeff Noebels |
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9:00–10:00 p.m. | General Discussion | |
Thursday, October 16, 2008 | ||
7:30–8:30 a.m. | Registration and Continental Breakfast | |
8:30–8:45 a.m. | Short Introduction-Charge to Participants | |
Session 1: Alzheimer’s Disease (AD) and Epilepsy? Clinical Dilemma Chair: Lennart Mucke |
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Suggested Topics (10-minute talks followed by 10-minute discussions) | ||
8:45–9:05 a.m. | A Review of Co-Morbidities of AD and Epilepsy Allen Hauser and Nick Scarmeas |
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9:05–9:25 a.m. | Cognitive Impairment in AD and Epilepsy Bruce Hermann |
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9:25–9:45 a.m. | Detection of Nonconvulsive Seizure Activity Andy Cole |
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9:45–10:05 a.m. | fMRI for the Measurement of Mesial Temporal Activity Jean Gotman |
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10:05–10: 30 a.m. | Coffee Break | |
10:30–10:50 a.m. | Neuronal Network Dysfunction in AD Brain Bradford Dickerson |
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10:50–11:20 a.m. | Discussion | |
Session 2: Clinical Trial Design | ||
Chairs: Marc Dichter and Jacqueline French | ||
11:20–11:40 a.m. | Designing a Clinical Trial for Antiepileptic Drugs in Dementia I Jacqueline French |
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11:40–12:00 a.m. | Designing a Clinical Trial for Antiepileptic Drugs in Dementia II Steven DeKosky |
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12:00–12:30 p.m. | Working Lunch | |
Session 3: Shared Mechanisms | ||
Chair: Helen Scharfman | ||
1:30–1:50 p.m. | Neuronal Dysfunction and Remodeling in Alzheimer’s Models Jorge Palop |
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1:50–2:10 p.m. | Neuronal Dysfunction and Remodeling in Epilepsy Models Asla Pitkaanen |
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2:10–2:30 p.m. | Pharmacology of Epilepsy and Dementia:A Synaptic Perspective Ray Dingledine |
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2:30–3:00 p.m. | Pharmacologies of Theraputics for AD and Epilepsy Jim Cloyd |
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3:00–3:20 p.m. | Coffee Break | |
3:20–3:50 p.m. | Discussion | |
Session 4: Genetic Models | ||
Chair: Jeff Noebels | ||
4:00–4:20 p.m. | Genes and Mechanisms of AD Gerard Schellenberg |
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4:20–4:40 p.m. | Genes and Mechanisms of Epilepsy Thomas Sutula |
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4:40–5:10 p.m. | Discussion | |
6:00 p.m. | Dinner | |
Friday, October 17, 2008 | ||
7:30–8:30 a.m. | Continental Breakfast | |
Session 5: Specific Recommendations for Moving Forward | ||
8:30–9:00 a.m. | The Clinical Perspective Jacqueline French and Steve DeKosky |
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9:00–9:45 a.m. | General Discussion | |
9:45–10:00 a.m. | Coffee Break | |
10:00–10:30 a.m. | The Basic Neuroscience Perspective Lennart Mucke and Jeff Noebels |
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10:30–11:30 a.m. | General Discussion | |
11:30–12:00 p.m. | General Discussion and Wrap-Up | |
12:00 p.m. | Adjourn |
Matthew P. Anderson, M.D., Ph.D. Beth Israel Deaconess/Harvard Medical School |
Seetha Bhagavan, Ph.D. CSR/NIH |
Debbie Carr Epilepsy Foundation |
Tracy Chen, Ph.D., DABT NINDS/NIH |
James Cloyd, Pharm.D. University of Minnesota |
Andrew Cole, M.D., FRCP(C) Harvard Medical School |
Steve Dekosky, M.D. University of Virginia School of Medicine |
Marc A. Dichter, M.D., Ph.D. University of Pennsylvania |
Bradford C. Dickerson, M.D. Harvard Medical School |
Ray Dingledine, Ph.D. Emory University School of Medicine |
Cerise Elliott, Ph.D. NIA/NIH |
Rene Etcheberrigaray, M.D. CSR/NIH |
Jacqueline French, M.D. New York University School of Medicine |
Brandy Fureman, Ph.D. NINDS/NIH |
Michela Gallagher, Ph.D. Johns Hopkins University |
Alison Goate, D.Phil. Washington University School of Medicine |
Jean Gotman, Ph.D. McGill University |
Gunnar Gouras, M.D. Weill Cornell Medical College |
Allen Hauser, M.D. Columbia University |
Bruce Hermann, Ph.D. University of Wisconsin School of Medicine and Public Health |
Margaret Jacobs NINDS/NIH |
Joanna Jankowsky, Ph.D. Baylor College of Medicine |
Kevin M. Kelly, M.D, Ph.D. Drexel University College of Medicine |
Melinda Kelley, Ph.D. NINDS/NIH |
Ti Lin, Ph.D. NINDS/NIH |
Carrie McDonald, Ph.D. University of California, San Diego |
Guy McKhann, M.D. Johns Hopkins University |
Istvan Mody, Ph.D. UCLA School of Medicine |
John C. Morris, M.D. Washington University in St. Louis |
Marcelle Morrison-Bogorad, Ph.D. NIA/NIH |
Lennart Mucke, M.D. University of California, San Francisco |
Suzan Nadi, Ph.D. CSR/NIH |
Dan Nicholson, Ph.D. Northwestern University Feinberg |
Jeffrey L. Noebels, M.D., Ph.D. Baylor College of Medicine |
Jorge J. Palop, Ph.D. University of California, San Francisco |
Manisha Patel, Ph.D. University of Colorado Denver |
Suzana Petanceska, Ph.D. NIA/NIH |
Creighton H. Phelps, Ph.D. NIA/NIH |
Joann Pierce Epilepsy Foundation |
Asla Pitkänen, M.D., Ph.D. University of Kuopio |
Larry Refolo, Ph.D. NINDS/NIH |
Erik Roberson, M.D., Ph.D. University of Alabama at Birmingham |
Lynn Rundhaugen, M.P.H. NINDS/NIH |
Laurie Ryan, Ph.D. NIA/NIH |
Nikos Scarmeas, M.D., M.Sc. Columbia University Medical Center |
Helen Scharfman, Ph.D. New York University |
Gerard D. Schellenberg, Ph.D. University of Pennsylvania Medical School |
Catherine Schevon, M.D., Ph.D. Columbia University |
Liz Schreiber Epilepsy Foundation |
Nina Silverberg, Ph.D. NIA/NIH |
D. Stephen Snyder, Ph.D. NIA/NIH |
James P. Stables, M.S. Admin. NINDS/NIH |
John Stern, M.D. UCLA School of Medicine |
Margaret Sutherland, Ph.D. NINDS/NIH |
Thomas P. Sutula, M.D., Ph.D. University of Wisconsin |
Christina Vert, M.S. NINDS/NIH |
Molly V. Wagster, Ph.D. NIA/NIH |
Karen Wilcox, Ph.D. University of Utah |
Bradford Wise, Ph.D. NIA/NIH |
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Last updated March 02, 2009