Biodefense Grants and Contracts:
FY2006 Awards
In fiscal year (FY) 2006, NIAID awarded a number of grants and contracts to expand scientific research and development for biodefense. These initiatives have been categorized according to the following four areas:
- Basic Research—programs to investigate pathogen biology, host response, microbial genomic sequencing, and proteomics
- Product Development—initiatives to support all phases of development of a candidate product or platform technology, including development of vaccines, therapeutics, and diagnostics
- Clinical Research—initiatives to evaluate biodefense therapies, vaccines, and diagnostics
- Research Resources—initiatives to build biodefense research capacity and infrastructure
Details concerning specific initiatives and related award information may be found below.
Biodefense and Emerging Infectious Diseases Research Opportunities
Objective: To encourage the submission of investigator-initiated research grant applications in biodefense and select emerging infectious diseases. The goal is to expedite research leading to the diagnosis, prevention, and treatment of diseases caused by potential bioterrorism agents.
Contact Info
Dr. Samuel Perdue
E-mail: sp189u@nih.gov
Innate Immunity to NIAID Category B Protozoa
Objective: To discover the cellular/molecular/biochemical mechanisms by which the mammalian innate immune system responds to NIAID Category B Priority Pathogens.
Contact Info
Tonu Wali
E-mail: twali@niaid.nih.gov
Training and Career Development for Biodefense and Emerging Diseases
Objective: To ensure that an adequate cadre of well-trained and motivated investigators are available to pursue research and development objectives in biodefense and emerging diseases.
Contact Info
Dr. Susan Garges
E-mail: sgarges@niaid.nih.gov
Assays for Influenza Therapeutics: Project BioShield
Objective: To develop high-throughput in vitro screening assays for influenza antiviral therapeutics incorporating validated, high-priority, biochemical targets.
Contact Info
Karen Lacourciere
E-mail: lacourcierek@niaid.nih.gov
Cooperative Research Partnerships for Biodefense
Objective: To support the discovery, design, and development of vaccines, therapeutics, adjuvants, and diagnostics for NIAID Category A, B, and C priority pathogens and toxins.
Contact Info
General scientific, technical, and programmatic issues: Michael Schaefer
E-mail: mschaefer@niaid.nih.gov
Vaccines: Lanling Zou
E-mail: lanlingz@niaid.nih.gov
Adjuvants: David Winter
E-mail: dwinter@niaid.nih.gov
Therapeutics: Mark Challberg
E-mail: mchallberg@niaid.nih.gov
Immunotherapeutics: Alison Deckhut
E-mail: adeckhut@niaid.nih.gov
Diagnostics: Maria Giovanni
E-mail: MGiovanni@niaid.nih.gov
Development of Therapeutic Agents for Selected Viral Diseases
Objective: To develop new, safe, and effective therapeutics for Variola major and viral hemorrhagic fevers, viral encephalitides, and influenza.
Contact Info
Dr. Katherine Taylor
E-mail: kataylor@niaid.nih.gov
Neutralizing Monoclonal Antibodies for Type A Botulinum Neurotoxins
Objective: Formulate a mixture of three human-compatible monoclonal antibodies to be evaluated as a treatment for exposure to botulinum neurotoxin serotypes A1 and A2. The contract also includes the performance of investigational new drug-enabling studies and long-term stability bulk drug substance and final drug product.
Contact Info
Dr. Katherine Taylor
E-mail: kataylor@niaid.nih.gov
NIAID Small Business Biodefense Program
Objective: To encourage Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) applications to develop therapeutics, vaccines, adjuvants/immunostimulants, diagnostics, and selected resources for biodefense.
Contact Info
Dr. Barbara Mulach
E-mail: bmulach@nih.gov
NIAID Clinical Trial Planning (R34) Grants
Objective: To support planning, design of, and documentation for investigator-initiated Phase I, II, III, and IV clinical trials.
Contact Info
Division of AIDS: Karen Reese
E-mail: kreese@niaid.nih.gov
Division of Allergy, Immunology, and Transplantation: Josiah Wedgwood
E-mail: JWedgwood@niaid.nih.gov
Division of Microbiology and Infectious Diseases: Shy Shorer
E-mail: shorers@niaid.nih.gov
NBL Operations Cooperative Agreements
Objective: To support operations of NIAID National Biocontainment Laboratories (NBL).
Contact Info
Rona Hirschberg
E-mail: rhirschberg@niaid.nih.gov
Services for Pre-Clinical Development of Therapeutic Agents
Objective: To establish a resource to facilitate preclinical development of therapeutic agents (drugs or biological products), including activities required for Investigational New Drug applications.
Contact Info
Beth Spinelli
E-mail: spinellb@niaid.nih.gov
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