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Genetics of Obsessive-Compulsive Disorder
This study is currently recruiting participants.
Verified by National Institutes of Health Clinical Center (CC), August 2008
Sponsored by: National Institute of Mental Health (NIMH)
Information provided by: National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier: NCT00001548

The purpose of this study is to identify genes that affect susceptibility to obsessive-compulsive disorder (OCD). By identifying genes that increase or decrease the risk of OCD, researchers can better understand how the condition develops and ultimately improve treatment for people with OCD.

OCD is a severe, familial condition that affects approximately 2% of the population. The way OCD is inherited is not clearly understood, but researchers believe it is complex and involves multiple genes. This study will detect and localize genes that increase or decrease susceptibility to OCD. The data collected from this study will be combined with data from other research studies to determine gene linkage and association.

Obsessive Compulsive Disorder

Genetics Home Reference related topics: Tourette syndrome
MedlinePlus related topics: Mental Health Obsessive-Compulsive Disorder
U.S. FDA Resources
Study Type: Observational
Official Title: Genetics of Obsessive-Compulsive Disorder: A Collaborative Study

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 1500
Study Start Date: August 1996
Detailed Description:

Obsessive-compulsive disorder (OCD) is a severe, heritable condition with a lifetime prevalence of about two percent of the population. The mode of inheritance is poorly understood but is likely complex, involving multiple loci of small to major effect. Since 1995, the NIMH-IRP has been active in a multi-center family study of OCD, led by Dr. Gerald Nestadt of Johns Hopkins University, which was approved via a competitive NIMH extramural application (MH 502140). An expanded consortium of sites (including new sites at Brown and Harvard Universities) anticipates adding 300 new affected sib-pair families over the next three years. This sample will be used for linkage and association analyses. Data will be shared within this consortium of investigators studying OCD, and will eventually be combined with data obtained from a second consortium.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Must have a diagnosis of obsessive-compulsive disorder, or be a family member (usually a parent or sibling) of someone with obsessive-compulsive disorder.

Certain disorders are considered part of OCD "spectrum" disorders and often include family members with OCD. These include Tourette's Syndrome, other individuals with tics, and Trichotillomania (severe hair pulling), and other forms of repetitive behaviors.

Persons with primary behavioral difficulties who do no fit with the current definitions of "OCD and OCD spectrum disorders" may not be eligible. These include compulsive shopping, gambling, or compulsive sexual behaviors.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001548

Contact: Diane M. Kazuba (301) 496-8977 kazubad@intra.nimh.nih.gov

United States, Connecticut
Yale University Recruiting
New Haven, Connecticut, United States, 06510-8005
United States, Florida
Florida State University Recruiting
Tallahassee, Florida, United States, 32306
United States, Maryland
Johns Hopkins University Recruiting
Baltimore, Maryland, United States, 21205
United States, Massachusetts
Harvard University Recruiting
Boston, Massachusetts, United States, 02115
United States, North Carolina
Duke University Recruiting
Durham, North Carolina, United States, 27710
United States, Rhode Island
Brown University Recruiting
Providence, Rhode Island, United States, 02912
United States, Tennessee
Vanderbilt University Recruiting
Nashville, Tennessee, United States, 37232
University of Newcastle Recruiting
Newcastle, Australia
Sponsors and Collaborators
  More Information

NIH Clinical Center Detailed Web Page  This link exits the ClinicalTrials.gov site

Study ID Numbers: 960124, 96-M-0124
Study First Received: November 3, 1999
Last Updated: September 5, 2008
ClinicalTrials.gov Identifier: NCT00001548  
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Psychiatric Disorder
Affected Sib Pairs
Family Study
OCD Spectrum Disorders
Tourette's Syndrome

Study placed in the following topic categories:
Compulsive Behavior
Anxiety Disorders
Mental Disorders
Gilles de la Tourette's syndrome
Tourette Syndrome
Obsessive-Compulsive Disorder

Additional relevant MeSH terms:
Pathologic Processes

ClinicalTrials.gov processed this record on January 30, 2009