Cancer research has led to real progress in prostate cancer detection, treatment, and supportive care. Because of research, men with prostate cancer can look forward to a better quality of life and less chance of dying from the disease. Continuing research offers hope that, in the future, even more men with this disease will be treated successfully.

Doctors all over the country are conducting many types of clinical trials (research studies in which people volunteer to take part). Clinical trials are designed to answer important questions and to find out whether new approaches are safe and effective.

Doctors are studying many types of treatment and their combinations:

• Active surveillance: Doctors are comparing having surgery or radiation right away to choosing active surveillance. The results of the study will help doctors know whether to treat early stage prostate cancer right away, or only when symptoms appear or get worse.
  
  
• Cryosurgery: Surgeons are studying a tool that freezes and kills prostate tissue in men with early prostate cancer.
  
  
• High-intensity focused ultrasound (HIFU): Doctors are testing HIFU in men with early prostate cancer. A probe is placed in the rectum. The probe gives off high-intensity ultrasound waves that heat up and destroy the prostate tumor.
  
  
• Radiation therapy: Doctors are using different doses or schedules of radiation therapy. They are looking at the use of radioactive implants after external radiation. And they are combining radiation therapy with other treatments, such as hormone therapy.
  
  
• Hormone therapy: Researchers are studying different schedules of hormone therapy, and they are combining it with other treatments.
  
  
• Chemotherapy: Researchers are testing anticancer drugs and combining them with hormone therapy or biological therapy. Chemotherapy allows some men to live longer and with a better quality of life.
  
  
• Biological therapy: New biological therapies are under study. For example, doctors are testing cancer vaccines that help the immune system kill cancer cells.

Doctors are also testing ways to manage the problems caused by prostate cancer and its treatment. For example, they are studying ways to manage or prevent bone pain, bone thinning, hot flashes, and impotence.

Even if the men in a trial do not benefit directly, they may still make an important contribution by helping doctors learn more about prostate cancer and how to control it. Although clinical trials may pose some risks, doctors do all they can to protect their patients.

If you're interested in being part of a clinical trial, talk with your doctor. You may want to read the NCI booklet Taking Part in Cancer Treatment Research Studies. It describes how treatment studies are carried out and explains their possible benefits and risks.

NCI's Web site includes a section on clinical trials at http://www.cancer.gov/clinicaltrials. It has general information about clinical trials as well as detailed information about specific ongoing studies of prostate cancer. NCI's Information Specialists at 1-800-4-CANCER or at LiveHelp at http://www.cancer.gov/help can answer questions and provide information about clinical trials.

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