Duke University

Cross-Species Analysis of Myocardial Susceptibility to Perioperative Stress

Mihai Podgoreanu, M.D.
mihai.podgoreanu@duke.edu

Project Description

The purpose of this grant is to develop a strategy that utilizes microarray technology. The protocol will identify candidate genes that contribute to perioperative myocardial injury (PMI) in two animal models of cardiac surgery (rat and pig) and in banked tissue samples collected intraoperatively from cardiac surgical patients. The ultimate intent is to investigate the relevance of DNA sequence variation in these candidate genes to susceptibility for PMI in a large population-based study. It is hypothesized that inherited DNA sequence variation in these candidate genes may be partly responsible for inter-individual variation in susceptibility to PMI. This application is relevant to the mission of both NIEHS and the National Heart Lung and Blood Institute (NHLBI). NHLBI funds this grant.