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Laboratory of Molecular Biophysics (LMB)
Nico Tjandra, PhD, Principal Investigator
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Comparison
of the N-terminal tail of the human and yeast Fis1 protein.
The yeast Fis1 N-terminal sits in the hydrophobic groove
of the protein. Read
More
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The mission of the Laboratory of Molecular Biophysics is to combine biophysical techniques to elucidate
the mechanism of function of biological macromolecules. There is a strong optical component of the
laboratory that develops and applies laser imaging as well as spectroscopy. Laser imaging is a crucial
and still rapidly advancing tool to study protein-protein and protein-substrate interaction as well as
their localization in the living cells. This is complemented by the laser spectroscopy that provides
information on the physical property and dynamics of the system. In addition the structural component
of the laboratory characterizes and determines macromolecular structures in their physiological solution
environment. Its primary focus is on the application and development of Nuclear Magnetic Resonance
techniques to determine biomolecular structure and dynamic at the atomic level. All of these components
provide complementary information on biological processes that cover a wide range of time scales.
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