References
Akesson A, Lundh T, Vahter M, Bjellerup, Lidfeltdt J, Nerbrand C, et al. 2005. Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 113:1627–1631.
Barth A, Schaffer AW, Osterode W, Winker R, Konnaris C, Valic E, et al. 2002. Reduced cognitive abilities in lead-exposed men. Int Arch Occup Environ Health 75: 394–398.
Borja-Aburto VH, Hertz-Picciotto I, Lopez MR, Farias P, Rios C, Blanco J. 1999. Blood lead levels measured prospectively and risk of spontaneous abortion. Am J Epidemiol 150: 590–597.
CDC. 2002. Managing Elevated BLLs Among Young Children. Atlanta:Centers for Disease Control and Prevention, National Center for Environmental Health.
CDC. 2005. Third National Report on Human Exposure to Environmental Chemicals. NCEH Publ no 05-0570. Atlanta:Centers for Disease Control and Prevention.
Chuang HY, Chao KY, Tsai SY. 2005. Reversible neurobehavioral performance with reductions in blood lead levels–a prospective study on lead workers. Neurotox Teratol 27:497–504.
Chuang HY, Schwartz J, Gonzales-Cossio T, Lugo MC, Palazuelos E, Aro A, et al. 2001. Interrelations of lead levels in bone, venous blood, and umbilical cord blood with exogenous lead exposure through maternal plasma lead in peripartum women. Environ Health Perspect 109:527–532.
Coyle P, Kosnett MJ, Hipkins KL. 2005. Severe lead poisoning in the plastics industry: a report of three cases. Am J Ind Med 47:172–175.
Cremin JD, Luck ML, Laughlin NK, Smith DR. 1999. Efficacy of succimer chelation for reducing brain lead in a primate model of human lead exposure. Toxicol Appl Pharmacol 161:283–293.
Den Hond E, Nawrot T, Staessen JA. 2002. The relationship between blood pressure and blood lead in NHANES III. National Health and Nutritional Examination Survey. J Hum Hypertens 16:563–568.
Dietrich KN, Ware JH, Salganik M, Radcliff J, Rogan WJ, Rhoads GG, et al. 2004. Effect of chelation therapy on the neuropsychological and behavioral development of lead-exposed children after school entry. Pediatrics 114: 19–26.
Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Peterson KE, Schwartz J, Aro A, et al. 2006. Influence of maternal bone lead burden and calcium intake on levels of lead in breast milk over the course of lactation. Am J Epidemiol 163:48–56.
Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Bellinger D, Peterson J, Schwartz J, Hu H, Hernandez-Avila M. 2004a. Effect of breast milk lead on infant blood lead levels at 1 month of age. Environ Health Perspect 112:1381–1385.
Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Gonzalez-Cossio T, Peterson KE, Aro A, et al. 2004b. Levels of lead in breast milk and their relation to maternal blood and bone lead levels at one-month postpartum. Environ Health Perspect 112:926–931.
Fine BP, Vetrano T, Skurnick J, Ty A. 1988. Blood pressure elevation in young dogs during low-level lead poisoning. Toxicol Appl Pharmacol 93:388–393.
Gerhardsson L, Chettle DR, Englyst V, Nordberg GF, Nyhlin H, Scott MC, et al. 1992. Kidney effects in long-term exposed lead smelter workers. Br J Ind Med 49: 186–192.
Goldstein GW, Asbury AK, Diamond I. 1974. Pathogenesis of lead encephalopathy. Uptake of lead and reaction of brain capillaries. Arch Neurol 31:382–389.
Gonzalez-Cossio T, Peterson KE, Sanín L, Fishbein SE, Palazuelos E, Aro A, et al. 1997. Decrease in birth weight in relation to maternal bone lead burden. Pediatrics 100:856–862.
Gomaa A, Hu H, Bellinger D, Schwartz J, Tsaih S, Gonzalez-Cossio T, et al. 2002. Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study. Pediatrics 110:110–118.
Gonick HC, Ding Y, Bondy SC, Ni Z, Vaziri ND. 1997. Lead-induced hypertension: interplay of nitric oxide and reactive oxygen species. Hypertension 30:1487–1492.
Gulson BL, Jameson CW, Mahaffey KR, Mizon KJ, Patison N, Law A, et al. 1998. Relationship of lead in breast milk to lead in blood, urine, and diet of the infant and mother. Environ Health Perspect 106:667–674.
Gulson BL, Mizon KJ, Korsch MJ, Mahaffey KR, Taylor AJ. 2001. Dietary intakes of selected elements from longitudinal 6-day duplicate diets for pregnant and nonpregnant subjects and elemental concentrations of breast milk and infant formula. Environ Res 87:160–174.
Hänninen H, Aitio A, Kovala T, Luukkonen R, Matikainen E, Mannelin T, et al. 1998. Occupational exposure to lead and neuropsychological dysfunction. Occup Environ Med 55:202–209.
Harlan WR. 1988. The relationship of blood lead levels to blood pressure in the U.S. population. Environ Health Perspect 78:9–13.
Hernandez-Avila M, Peterson KE, Gonzalez-Cossio T, Sanin LH, Aro A, Schnaas L, et al. 2002. Effect of maternal bone lead on length and head circumference at birth. Arch Environ Health 57:482–488.
Hertz-Picciotto I. 2000. The evidence that lead increases the risk for spontaneous abortion. Am J Ind Med 38:300–309.
Hipkins KL, Materna BL, Payne S, Kirsch L. 2004. Family lead poisoning due to occupation. Clin Pediatr 43: 845–849.
Hofreuter DH, Catcott EJ, Keenan RG, Xintaras C. 1961. The public health significance of atmospheric lead. Arch Environ Health 3:568–574.
Hu H, Aro A, Payton M, Korrick S, Sparrow D, Weiss ST, et al. 1996. The relationship of bone and blood lead to hypertension. JAMA 275:1171–1176.
Hu H, Shih R, Rothenberg S, Schwartz BS. 2007. The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues. Environ Health Perspect 115:455–462.
Hu H, Téllez-Rojo MM, Bellinger D, Smith D, Ettinger AS, Lamadrid-Figueroa H, et al. 2006. Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development. Environ Health Perspect doi: 10.1289/ehp.9067 available via http://dx.doi.org/ [Online 19 July 2006].
Janakiraman V, Hu H, Mercado-Garcia A, Hernandez-Avila M. 2003. A randomized crossover trial of nocturnal calcium supplements to suppress bone resorption during pregnancy. Am J Prev Med 24:260–264.
Korrick SA, Hunter DJ, Rotnitzky A, Hu H, Speizer FE. 1999. Lead and hypertension in a sample of middle-aged women. Am J Public Health 89:330–335.
Kosnett MJ. 2001. Lead. In: Clinical Toxicology (Ford M, Delaney KA, Ling L, Erickson T, eds). St. Louis:WB Saunders, 723–736.
Kosnett MJ. 2005. Lead. In: Critical Care Toxicology (Brent J, Wallace KL, Burkhart KK, Phillips SD, Donovan JW, eds). Philadelphia:Elsevier Mosby, 821–836.
Krieg EF, Chislip DW, Crespo CJ, Brightwell WS, Ehrenberg RL, Otto D. 2005. The relationship between blood lead levels and neurobehavioral test performance in NHANES III and related occupational studies. Public Health Rep 120:240–251.
Lilis R, Gavrilescu N, Nestorescu B, Dumitriu C, Roventa A. 1968. Nephropathy in chronic lead poisoning. Br J Ind Med 25:196–202.
Lindgren KN, Ford DP, Bleeker ML. 2003. Pattern of blood lead levels over working lifetime and neuropsychological performance. Arch Environ Health 58: 373–379.
Lustberg M, Silbergeld E. 2002. Blood lead levels and mortality. Arch Intern Med 162:2443–2449.
Mahaffey KR, Annest JL, Roberts J, Murphy RS. 1982. National estimates of blood lead levels: United States, 1976–1980. N Engl J Med 307:573–579.
Mantere P, Hänninen H, Hernberg S, Luukkonen R. 1984. A prospective follow-up study on psychological effects in workers exposed to low-levels of lead. Scand J Work Environ Health 10:43–50.
Manton WI, Angle CR, Stanek KL, Reese YR, Kuehnemann TJ. 2000. Acquisition and retention of lead by young children. Environ Res 82:60–80.
Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. 2006. Blood lead below 0.48 µmol/L (10 µg/dL) and mortality among US adults. Circulation 114: 1388–1394.
Minot AS. 1938. The physiological effects of small amounts of lead: an evaluation of the lead hazard of the average individual. Physiol Rev 18:554–577.
Muldoon SB, Cauley JA, Kuller LH, Morrow L, Needleman HL, Scott J, et al. 1996. Effects of blood lead levels on cognitive function of older women. Neuroepidemiology 15:62–72.
Muntner P, Vupputuri S, Coresh J, Batuman V. 2003. Blood lead and chronic kidney disease in the general United States population: results from NHANES III. Kidney Int 63:104–150.
Nash D, Magder L, Lustberg M, Sherwin R, Rubin R, Kaufmann R, et al. 2003. Blood lead, blood pressure, and hypertension in perimenopausal and postmenopausal women. JAMA 289:1523–1531.
National Center for Health Statistics. 1984. Blood lead levels for persons ages 6 months to 74 years. United States, 1976-1980. Vital and Health Statistics. Ser 11, no 233. Publ no (PHS) 84-1683. Washington, DC:National Center for Health Statistics.
Nawrot TS, Thijs L, Den Hond EM, Roels HA, Staessen JA. 2002. An epidemiological re-appraisal of the association between blood pressure and blood lead: a meta-analysis. J Hum Hypertens 16:123–131.
Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. 2007. Lead exposure and cardiovascular disease—a systematic review. Environ Health Perspect 115:472–482.
Occupational Lead Poisoning Prevention Program. 2006. Common Jobs, Hobbies & Other Sources of Lead. Richmond, CA:California Department of Health Services, Occupational Health Branch. Available: http://www.dhs.ca.gov/ohb/olppp/leadsources.pdf [accessed 14 December 2006]
OSHA (U.S. Occupational Safety and Health Administration). 2002. Safety and Health Topics: Lead. Compliance. Available: http://www.osha.gov/SLTC/lead/compliance.html [accessed 14 December 2006].
OSHA (U.S. Occupational Safety and Health Administration). 2005. Blood Lead Laboratories Program Description and Background. Available: http://www.osha.gov/SLTC/bloodlead/program.html [accessed 14 December 2006].
Parsons PJ, Reilly AA, Hussain A. 1991. Observational study of erythrocyte portoporphyrin screening test for detecting low lead exposure in children; impact of lowering the blood lead action threshold. Clin Chem 37: 216–225.
Payton M, Hu H, Sparrow D, Weiss ST. 1994. Low-level lead exposure and renal function in the Normative Aging Study. Am J Epidemiol 140:821–829.
Payton M, Riggs KM, Spiro A, Weiss ST, Hu H. 1998. Relations of bone and blood lead to cognitive function: the VA Normative Aging Study. Neurotoxicol Teratol 20: 19–27.
Piacitelli GM, Whelan EA, Ewers LM, Sieber WK. 1995. Lead contamination in automobiles of lead-exposed bridgeworkers. Appl Occup Environ Hyg 10:849–855.
Pocock SJ, Shaper AG, Ashby D, Delves HT, Clayton BE. 1988. The relationship between blood lead, blood pressure, stroke, and heart attacks in middle-aged British men. Environ Health Perspect 78:23–30.
Rabinowitz MB, Bellinger D, Leviton A, Needleman H, Schoenbaum S. 1987. Pregnancy hypertension, blood pressure during labor, and blood lead levels. Hypertension 10: 447–451.
Rogan WJ, Dietrich KN, Ware JH, Docery DW, Salganik M, Radcliffe J, et al. 2001. The effects of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med 344:1421–1426.
Roscoe RJ, Gittleman JL, Deddens JA, Petersen MR, Halperin WE. 1999. Blood lead levels among children of lead-exposed workers: a meta-analysis. Am J Ind Med 36:475–481.
Rothenberg SJ, Kondrashov V, Manalo M, Jiang J, Cuellar R, Garcia M, et al. 2002. Increases of hypertension and blood pressure during pregnancy with increased bone lead. Am J Epidemiol 156:1079–1087.
Rothenberg SJ, Manalo M, Jiang J, Cuellar R, Reyes S, Sanchez M, et al. 1999a. Blood lead levels and blood pressure during pregnancy in South Central Los Angeles. Arch Environ Health 54:382–389.
Rothenberg SJ, Schnaas L, Perroni E, Hernandez RN, Martinez S, Hernandez C. 1999b. Pre- and postnatal lead effect on head circumference: a case for critical periods. Neurotoxicol Teratol 21:1–11.
Sanín LH, González-Cossín T, Romieu I, Perterson KE, Ruíz S, Palazuelos E, Hernández-Avila M. Hu H. 2001. Effect of maternal lead burden on infant weight and weight gain at one month of age among breastfed infants. Pediatrics 107:1016–1023.
Schnaas L, Rothenberg SJ, Flores MF, Martinez S, Hernandez C, Osorio E, et al. 2006. Reduced intellectual development in children with prenatal lead exposure. Environ Health Perspect 111:791–797.
Schober SE, Miral B, Graudbard BI, Brody DJ, Flegal KM. 2006. Blood lead levels and death from all causes, cardiovascular disease, and cancer: results from the NHANES III mortality study. Environ Health Perspect 114: 1538–1541.
Schwartz BS, Hu H. 2007. Adult lead exposure: time for change. Environ Health Perspect 115: 451–454.
Schwartz BS, Lee BK, Lee GS, Stewart WF, Lee SS, Hwang KY, et al. 2001. Association of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers. Am J Epidemiol 153:453–464.
Schwartz BS, Lee BK, Bandeen-Roche K, Stewart W, Bolla K, Links J, et al. 2005. Lead dose is associated with longitudinal decline in neurobehavioral test scores in South Korean lead workers. Epidemiology 16: 106–113.
Schwartz J. 1988. The relationship between blood lead and blood pressure in NHANES II survey. Environ Health Perspect 78:15–22.
Schwartz J. 1995. Lead, blood pressure, and cardiovascular disease in men. Arch Environ Health 50: 31–37.
Sen D, Wolfson H, Dilworth M. 2002. Lead exposure in scaffolders during refurbishment construction activity–an observational study. Occup Med 52: 49–54.
Shih RA, Glass TA, Bandeen-Roche K, Carlson MC, Bolla KI, Todd AC, Schwartz BS. 2006. Environmental lead exposure and cognitive function in community-dwelling older adults. Neurology 14:1556–1562.
Shih RA, Hu H, Weisskopf MG, Schwartz BS. 2007. Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Environ Health Perspect 115:483–492.
Sinks T, Jackson RJ. 1999. International study finds breast milk free of significant lead contamination. Environ Health Perspect 107:A58–A59.
Sowers MR, Scholl TO, Hall G, Jannausch ML, Kemp FW, Li X, et al. 2002. Lead in breast milk and maternal bone turnover. Am J Obstet Gynecol 187:770–776.
Staeesen JA, Bulpitt CJ, Fagard R, Lauwerys RR, Roels H, Thijs L, Amery A. 1994. Hypertension caused by low-level lead exposure: myth or fact? J Cardiovasc Risk 1:87–97.
Staessen JA, Lauwerys RR, Buchet JP, Bulpitt CJ, Rondia D, Vanrenterghem Y, et al. 1992. Impairment of renal function with increasing blood lead concentrations in the general population. The Cadmibel Study Group. N Engl J Med 327: 151–156.
Staessen JA, Roels H, Fagard R. 1996. Lead exposure and conventional and ambulatory blood pressure: a prospective population study. PheeCad Investigators. JAMA 275: 1563–1570.
Stollery BT. 1996. Reaction time changes in workers exposed to lead. Neurotoxicol Teratol 18: 477–483.
Tellez-Rojo MM, Hernandez-Avila M, Lamadrid-Figueroa H, Smith D, Hernandez-Cadena L, Mercado A, et al. 2004. Impact of bone lead and bone resorption on plasma and whole blood lead levels during pregnancy. Am J Epidemiol 160: 668–678.
Theppeang K, Schwartz BS, Lee BK, Lustberg ME, Silbergeld EK, Kelsey KT, et al. 2004. Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. J Occup Environ Med 46:528–537.
Tsaih SW, Korrick S, Schwartz J, Amarasiriwardena C, Aro A, Sparrow D, et al. 2004. Lead, diabetes, hypertension, and renal function: Normative Aging Study. Environ Health Perspect 112:1178–1182.
U.S. EPA. 2006. Air Quality Criteria for Lead (Final). Washington, DC:U.S. Environmental Protection Agency, National Center for Environmental Assessment. Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=158823 [accessed 14 December 2006].
Vaziri ND. 2002. Pathogenesis of lead-induced hypertension: role of oxidative stress. J Hypertens 20(suppl 3):S15–S20.
Vupputuri S, He J, Munter P, Bazzano L, Whelton PK, Batuman V. 2003. Blood lead level is associated with elevated blood pressure in blacks. Hypertension 41: 463–468.
Wasserman GA, Liu X, Popovac D, Factor-Litvak P, Kline J, Waternaux C, et al. 2000. The Yugoslavia prospective lead study: contributions of prenatal and postnatal lead exposure to early intelligence. Neurotoxicol Teratol 22:811–818.
Weaver VM, Lee B-K, Ahn K-D, Lee G-S, Todd AC, Stewart WF, et al. 2003. Associations of lead biomarkers with renal function in Korean lead workers. Occup Environ Med 60:551–562.
Weaver VM, Lee BK, Todd AC, Ahn KD, Shi W, Jaar BG, et al. 2006. Effect modification by δ-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide sythase gene polymorphisms on associations between patella lead and renal function in lead workers. Environ Res 102:61–69.
Wedeen RP, Mallik DK, Batuman V. 1979. Detection and treatment of occupational lead nephropathy. Arch Intern Med 139:53–57.
Weisskopf MG, Proctor SP, Wright RO, Schwartz J, Spiro A, Sparrow D, Nie H, Hu H. 2007. Cumulative lead exposure and cognitive performance among elderly men. Epidemiology 18: 59–66.
Weisskopf MG, Wright RO, Schwartz J, Spiro III A, Sparrow D, Aro A, et al. 2004. Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. Am J Epidemiol 160:1184–1193.
Winker R, Barth A, Ponocny-Seliger E, Pilger A, Osterode W, Rudiger HW. 2005. No cognitive deficits in men formerly exposed to lead. Wein Klin Wochenschr 117: 755–760.
Winker R, Ponocny-Seliger E, Rudiger HW, Barth A. 2006. Lead exposure levels and duration of exposure absence predict neurobehavioral performance. Int Arch Occup Environ Health 79:123–127.
Wright RO, Tsaih SW, Schwartz J, Spiro A, McDonald K, Weiss ST, et al. 2003. Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology 14: 713–718.
Wu MT, Kelsey K, Schwartz J, Sparrow D, Weiss S, Hu H. 2003. A δ-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low level lead exposure to uricemia and renal function: the Normative Aging Study. Environ Health Perspect 111:335–341.
Last Updated: February 19, 2007