| Agent Name |
Hexamethylphosphoric triamide |
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| Alternative Name |
Hexamethyl phosphoramide |
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| CAS Number |
680-31-9 |
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| Formula |
C6-H18-N3-O-P |
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| Major Category |
Other Classes |
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| Synonyms |
Eastman Inhibitor HPT; HMPA; HMPT; HMPTA; Hempa; Hexametapol; Hexamethyl phosphoramide; Hexamethylfosforamid [Czech]; Hexamethylorthophosphoric triamide; Hexamethylphosphoramide; Hexamethylphosphoric acid triamide; Hexamethylphosphoric triamide; Hexamethylphosphorotriamide; Hexamethylphosphotriamide; N,N,N,N,N,N-Hexamethylphosphoric triamide; Phosphoric acid hexamethyltriamide; Phosphoric hexamethyltriamide; Phosphoric triamide, hexamethyl-; Phosphoric tris(dimethylamide); Phosphoryl hexamethyltriamide; Tris(dimethylamino)phosphine oxide; Tris(dimethylamino)phosphorus oxide; Tris-(dimethylamid) kyseliny fosforecne [Czech]; [ChemIDplus] |
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| Category |
Phosphorus Compounds |
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| Description |
Clear, colorless liquid with an aromatic or mild, amine-like odor. [Note: A solid below 43 degrees F.]; [NIOSH] |
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| Sources/Uses |
Used as a solvent for aromatic polyamide fibers; also used as a catalyst, stabilizer, and additive for polymers and resins; [ACGIH] |
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| Comments |
A TLV is not recommended because the absence of data. Rats suffer kidney injury and death after repeated inhalation exposures. HMPA is carcinogenic in animals. The TLV Basis is upper respiratory tract cancer. [ACGIH] May have effects on the lungs, kidneys, and bone marrow; [ICSC] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| Vapor Pressure |
0.03 mm Hg |
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| Lethal Concentration |
LCLo (rats) = 2,920 mg/m3/4h |
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| Explanatory Notes |
Carcinogen--No TLV; NIOSH REL = lowest feasible conc. Flash point = 222 deg F; |
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| Adverse Effects |
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| Nephrotoxin |
Yes |
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| IARC Carcinogen |
Possible Carcinogen |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: HEXAMETHYLPHOSPHORAMIDE
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