Bioinformatics Primers

Pathway Interaction Database provides reviews and commentary illuminating topics of particular interest.

July 2008

• An Introduction to COSMIC, the Catalogue of Somatic Mutations in Cancer

  

  COSMIC (Catalogue of Somatic Mutations in Cancer; http://www.sanger.ac.uk/cosmic) is a comprehensive resource that aims to curate the world's literature on somatic mutations in known cancer genes. The catalog includes full and up-to-date curation of mutation data in over 60 well known point-mutated genes, together with novel gene fusion products expressed across genome rearrangement breakpoints, and all of the somatic mutation data from candidate gene screens at the UK's Cancer Genome Project. This primer introduces the COSMIC web system and how it may be used by cancer researchers, together with downloads available for data mining by bioinformaticians.

  Original research paper Pathway Interaction Database doi:10.1038/pid.2008.3