The Association of Common Inherited Variants with Cancer Risk |
|
|---|---|
|
|
|
| Launch in standalone player | |
| Air date: | Wednesday, March 26, 2008, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Runtime: | 72 minutes |
| NLM Title: | The association of common inherited variants with cancer risk [electronic resource] / David J. Hunter. |
| Series: | NIH director's Wednesday afternoon lecture series |
| Author: | Hunter, David J. National Institutes of Health (U.S.) |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2008] |
| Other Title(s): | NIH director's Wednesday afternoon lecture series |
| Abstract: | (CIT): The cataloguing of human genes and determination of common genetic variation in the human genome presents the major challenge of determining how inherited genetic variation affects our health. Epidemiologists are responsible for assessing the proportion of specific diseases associated with particular genotypes, and how these genotypes interact with environmental and lifestyle factors in disease causation. The advent of the capacity to perform Genome-Wide Association Studies has led to a rapid series of findings relating common inherited variation with risk of common cancers and other diseases and phenotypes. These associations should lead to new mechanistic insights, as well as having the potential to offer individuals cancer risk assessment. These new methods have had a large impact on the practice of epidemiology. Large Consortia are necessary to generate the sample sizes necessary to obtain robust replication of genetic associations. Even larger sample sizes will be necessary to permit analysis of gene-gene and gene-environment interactions. Sharing of the full results from studies is critical, and can be achieved without compromising participant privacy or confidentiality. Translation of these findings into public health and clinical practice is complex, and made more complex by the sheer number of new findings. The new technologies that permit genome-wide assessment of common genetic variation in research studies, also permit the determination of these genotypes in individual consumers at low cost per genotype. The responsible incorporation of these new technologies into medical practice poses unprecedented challenges to our conventional models of evaluation of risk assessment tools in the population and the clinic. |
| Subjects: | Genetic Predisposition to Disease Neoplasms--epidemiology Neoplasms--genetics Risk |
| Publication Types: | Government Publications |
| Download: | Download
Video How to download a Videocast |
| NLM Classification: | QZ 200 |
| NLM ID: | 101470381 |
| CIT File ID: | 14393 |
| CIT Live ID: | 6216 |
| Permanent link: | http://videocast.nih.gov/launch.asp?14393 |
| Podcast information | ||||||
|---|---|---|---|---|---|---|
| Audio Podcasts | Video Podcasts | |||||
| Description | Runtime | Description | Runtime | |||
|
|
Enhanced Audio Podcast | 1:05:23 |
|
Enhanced Video Podcast | 1:05:23 | |