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| Descriptive Information Fields | |||||||||
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| Brief Title † | National Lung Screening Trial (NLST) | ||||||||
| Official Title † | National Lung Screening Trial | ||||||||
| Brief Summary | RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for lung cancer. It is not yet known whether helical CT scan is more effective than chest x-ray in reducing death from lung cancer. PURPOSE: Randomized clinical trial to compare the effectiveness of helical CT scan with that of chest x-ray in screening individuals who are at high risk for developing lung cancer. |
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| Detailed Description | OBJECTIVES:
OUTLINE: This is a randomized, multicenter study. Participants are randomized to 1 of 2 screening arms.
Participants will then be contacted annually by mail or telephone for several years. The National Lung Screening Trial (NLST) represents the union of two NCI-sponsored activities, the NCI Lung Screening Study I and the American College of Radiology Imaging Network (ACRIN). For more information, please access the ACRIN trial on Cancer.gov. The protocol ID is ACRIN-6654. PROJECTED ACCRUAL: A total of 50,000 participants will be accrued for this study within 2 years. |
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| Study Phase | |||||||||
| Study Type † | Interventional | ||||||||
| Study Design † | Screening, Randomized, Active Control | ||||||||
| Primary Outcome Measure † | |||||||||
| Secondary Outcome Measure † | |||||||||
| Condition † | Lung Cancer | ||||||||
| Intervention † | Procedure: bronchoscopic and lung imaging studies Procedure: comparison of screening methods |
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| MEDLINE PMIDs | 18024436 | ||||||||
| Links | Clinical trial summary from the National Cancer Institute's PDQ® database  Web site for additional information |
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| Recruitment Information Fields | |||||||||
| Recruitment Status † | Active, not recruiting | ||||||||
| Enrollment † | |||||||||
| Start Date † | September 2002 | ||||||||
| Completion Date | |||||||||
| Eligibility Criteria † | DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS: Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
PRIOR CONCURRENT THERAPY: Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
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| Gender | Both | ||||||||
| Ages | 55 Years to 74 Years | ||||||||
| Accepts Healthy Volunteers | No | ||||||||
| Contacts †† | |||||||||
| Location Countries † | United States | ||||||||
| Administrative Information Fields | |||||||||
| NCT ID † | NCT00047385 | ||||||||
| Organization ID | CDR0000257938 | ||||||||
| Secondary IDs †† | NCI-NLST, ACRIN-NCI-NLST | ||||||||
| Study Sponsor † | National Cancer Institute (NCI) | ||||||||
| Collaborators †† | American College of Radiology Imaging Network | ||||||||
| Investigators † |
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| Information Provided By | National Cancer Institute (NCI) | ||||||||
| Verification Date | April 2004 | ||||||||
| First Received Date † | October 3, 2002 | ||||||||
| Last Updated Date | July 23, 2008 | ||||||||
