Our Science – Morrison Website

Deborah K. Morrison, Ph.D.

Laboratory of Cell and Developmental Signaling Head, Cellular Growth Mechanisms Section Laboratory Chief Building 560, Room 22-90B NCI-Frederick Frederick, MD Phone:   301-846-1733 Fax:   301-846-1666 E-Mail:   dmorrison@ncifcrf.gov

Biography

Dr. Deborah Morrison obtained her Ph.D. from Vanderbilt University School of Medicine. She then began studying signal transduction as a postdoctoral fellow in the laboratories of Dr. Thomas Roberts at Harvard Medical School and Dr. Lewis Williams at the University of California-San Francisco. Dr. Morrison joined the ABL-Basic Research Program in 1990 and became head of the Cellular Growth Mechanisms Section in 1995. From 1996 to 1997, she was on sabbatical in the laboratory of Dr. Gerald Rubin at the University of California-Berkeley. In 1999, Dr. Morrison joined the Center for Cancer Research, NCI.

Research

Regulation of Signal Transduction Pathways

The proliferative state of normal cells is precisely regulated by signals received from the extracellular environment. Understanding how these signals are relayed from the cell surface to the nucleus is the major objective of the Cellular Growth Mechanisms Section. Studies in this area are particularly relevant to cancer research because release from regulatory controls at any point along the signaling cascade can result in uncontrolled cell growth or oncogenesis. We have chosen to focus our studies on the pathway regulated by the Ras GTPase, where our aims are to further elucidate the processes involved in signal transduction and to identify critical regulatory points linked to tumor formation.

The transmission of growth and developmental signals from the membrane to the nucleus requires the coordinated action of a diverse set of proteins. Previous work from our laboratory and others has demonstrated that the Raf-1 serine/threonine kinase serves as a central intermediate in many signaling pathways, functioning downstream of activated tyrosine kinases and Ras and upstream of mitogen-activated protein kinase (MAPK) and MAPK kinase (MKK or MEK). While Raf-1 is a critical component in signal transduction, the precise way in which Raf-1 becomes activated and inactivated during growth, development, and oncogenesis is not completely understood. Therefore, a major goal of our research has been to elucidate the mechanisms regulating Raf-1 activity and to determine the role that phosphorylation events and protein interactions play in the Raf-1 activation/inactivation process.

Our laboratory's research efforts have also focused on another protein involved in signal transduction, kinase suppressor of Ras (KSR). KSR was originally identified in Drosophila and C. elegans and is an evolutionarily conserved component of the Ras pathway. Our studies examining mammalian KSR are directed towards determining how this protein functions to transduce Ras-dependent signals.

Finally, our laboratory has had an ongoing interest in using the fruit fly, Drosophila, as a model system for studying signaling events. Our goal in this project is to use the powerful genetic techniques amenable to this system to further elucidate the pathways and proteins involved in the transmission of cellular signals.

This page was last updated on 6/18/2008.