National Toxicology Program

CASRN: 128-37-0

Formula: C15-H24-O

Synonyms/Common Names:

• BHT
• 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYLPHENOL (9CI)

Known Uses:

ANTIOXIDANT FOR PETROLEUM AND FOOD PRODUCTS; ANIMAL FEED; FOOD PACKAGING

Short-Term Toxicity

• 13-WEEK (Dosed-Feed)  (C03598) Completed 
  • NTIS No. PB298539  (Peer Review 12/13/1978)
    Citation: Bioassay of Butylated Hydroxytoluene (BHT) for Possible Carcinogenicity (CAS No. 128-37-0)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,6200,50000, M: 0,3100,50000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C03598) Report Complete 
  • TR-150 (NTIS No. PB298539)  (Peer Review 12/13/1978)
    Bioassay of Butylated Hydroxytoluene (BHT) for Possible Carcinogenicity (CAS No. 128-37-0)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: 0,3000,6000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (549686) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Mouse Lymphoma  (441614) Completed 
  • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
  •  Positive 
• Micronucleus  (A82929) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella  (377283) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative