Bioinformatics Primers

Pathway Interaction Database provides reviews and commentary illuminating topics of particular interest.

December 2007

• An Introduction to the Reactome Knowledgebase of Human Biological Pathways and Processes

  

  The human genome encodes approximately 25,000 proteins. Functional information is available for about half of these, either from direct studies of human proteins or from studies of well–conserved homologues in model organisms. The goal of the Reactome Project is to systematically associate these proteins with their functions in order to generate a consistently annotated knowledge–base of human biological processes that is useful both as an online reference for individual processes and as a data mining and analysis resource for systems biology.

  Original research paper Pathway Interaction Database doi:10.1038/pid.2007.3