| Effects of Environmental Agents on the Attainment of Puberty: Considerations When Assessing Exposure to Environmental Chemicals in the National Children’s Study Richard Y. Wang, Larry L. Needham, and Dana B. Barr National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA Abstract
The apparent decline in the age at puberty in the United States raises a general level of concern because of the potential clinical and social consequences of such an event. Nutritional status, genetic predisposition (race/ethnicity) , and environmental chemicals are associated with altered age at puberty. The Exposure to Chemical Agents Working Group of the National Children’s Study (NCS) presents an approach to assess exposure for chemicals that may affect the age of maturity in children. The process involves conducting the assessment by life stages (i.e., in utero, postnatal, peripubertal) , adopting a general categorization of the environmental chemicals by biologic persistence, and collecting and storing biologic specimens that are most likely to yield meaningful information. The analysis of environmental samples and use of questionnaire data are essential in the assessment of chemicals that cannot be measured in biologic specimens, and they can assist in the evaluation of exposure to nonpersistent chemicals. Food and dietary data may be used to determine the extent to which nutrients and chemicals from this pathway contribute to the variance in the timing of puberty. Additional research is necessary in several of these areas and is ongoing. The NCS is uniquely poised to evaluate the effects of environmental chemicals on the age at puberty, and the above approach will allow the NCS to accomplish this task. Key words: children, environmental chemicals, exposure assessment, hormonally active agents, National Children’s Study, puberty. Environ Health Perspect 113:1100-1107 (2005) . doi:10.1289/ehp.7615 available via http://dx.doi.org/ [Online 12 May 2005]
This article is part of the mini-monograph “Assessing Exposures to Environmental Agents during the National Children’s Study.” Address correspondence to R. Wang, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, MS-F17, Atlanta, GA 30341 USA. Telephone: (770) 488-7950. Fax: (770) 488-4546. E-mail: RYWang@cdc.gov The authors declare they have no competing financial interests. Received 20 September 2004 ; accepted 14 March 2005. The full version of this article is available for free in HTML or PDF formats. |
