Dr. Peter Ghazal joined our lab in 1986 to explore the enhancer of the immediate early 1 gene of the humen cytomegalovirus. Peter discovered the formation of a large multi-component complex on the enhancer and he identified a number of transcription factors and DNA binding proteins, most notably NF1, interacting with enhancer sequences. He established an in vitro transcription system to understand the molecular function of the enhancer. Peter left in 1988 to take a faculty position at the Scripps and returned in 1999 to his native Scotland.
Dr. Gazal is currently a Professor of Virology at the University of Edinburg (Ghazal lab)
Publications while at LGP
Ghazal, P., Lubon, H., Reynolds-Kohler, C., Hennighausen, L., and Nelson, J.A. (1990). Interactions between cellular regulatory proteins and a unique sequence region in the human cytomegalovirus major immediate-early promoter. Virology 174, 18-25.
Dean, D.C., Blakeley, M.S., Newby, R.F., Ghazal, P., Hennighausen, L., and Bourgeois, S. (1989). Forskolin inducibility and tissue-specific expression of the fibronectin promoter. Mol. Cell. Biol. 9, 1498-1506.
Lubon, H., Ghazal, P., Hennighausen, L., Reynolds-Kohler, C., Lockshin, C. and Nelson, J. (1989). Cell-specific activity of the modulator region in the human cytomegalovirus major immediate early gene. Mol. Cell. Biol. 9, 1342-1345.
Lubon, H., Ghazal, P., Nelson, J. and Hennighausen, L. (1988). Cell-specific activity of the human immnodeficiency virus enhancer repeat in vitro. AIDS Research and Human Retroviruses 4, 381-391.
Ghazal, P., Lubon, H. and Hennighausen, L. (1988). Specific interactions between transcription factors and the promoter-regulatory region of the human cytomegalovirus major immediate early gene. J. Virol 62, 1076-1079.
Ghazal, P., Lubon, H. and Hennighausen, L. (1988). Multiple sequence specific transcription factors modulate cytomegalovirus enhancer activity in vitro. Mol. Cell. Biol. 8, 1809-1811.
Ghazal, P., Lubon, H., Fleckenstein, B. and Hennighausen, L. (1987). Binding of transcription factors and the creation of a large nucleoprotein complex on the human cytomegalovirus enhancer. Proc. Natl. Acad. Sci. U.S.A. 84, 3658-3662.