Advisory Board & Committees
BSC RoC Subcommittee: Tentative Review Substances November 18-19, 1996
| Azacitidine | CAS Number 320-67-2 | Review order: 3 | |
| Primary Uses: | Used as a cytostatic agent in the treatment of acute leukemia. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| p-Chloro-o-toluidine and its HCl salt | CAS Number 95-69-2 | Review order: 4 | |
| Primary Uses: | Used to produce azo dyes for cotton, silk acetate and nylon and as intermediate in production of Pigment Red 7 and Pigment Yellow 49. Also an impurity in and a metabolite of the pesticide chlordimeform. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| Chlorozotocin | CAS Number 54749-90-5 | Review order: 5 | |
| Primary Uses: | Used as a cytostatic agent in the treatment of cancers of the stomach, large intestine pancreas and lung; melanoma; and multiple myeloma. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| Cyclosporin | CAS Number 59865-13-3 | Review order: 1 | |
| Primary Uses: | Used as an immunosuppressive agent in the prevention and treatment of graft-vs-host reactions in bone marrow transplantation and for the prevention of rejection of kidney, heart, and liver transplants. | ||
| Nominated as: | Known to be a Human Carcinogen | ||
| Danthron (1,8-Dihydroxyanthraquinone) | CAS Number 117-10-2 | Review order: 12 | |
| Primary Uses: | Used as a laxative and as an intermediate in the manufacture of dyes. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| 1,6-Dinitropyrene | CAS Number 42397-64-8 | Review order: 9 | |
| Primary Uses: | Not used commercially, detected in ambient atmospheric samples and as a constituent of diesel exhaust. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| 1,8-Dinitropyrene | CAS Number 42397-65-9 | Review order: 10 | |
| Primary Uses: | Not used commercially, detected in ambient atmospheric samples and as a constituent of diesel exhaust. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| Disperse Blue 1 (1,4,5,8-Tetraaminoanthraquinone) | CAS Number 2475-45-8 | Review order: 13 | |
| Primary Uses: | Used as an anthraquinone based dyestuff in hair color formulations and in coloring fabrics and plastics. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| Furan | CAS Number 100-00-9 | Review Order 6 | |
| Primary Uses: | Used as an intermediate in the synthesis and production of other organic compounds. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| o-Nitroanisole | CAS Number 91-23-6 | Review Order 14 | |
| Primary Uses: | Used as a precursor in the synthesis of o-anisidine which is used in the manufacture of over100 azo dyes. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| 6-Nitrochrysene | CAS Number 7495-02-8 | Review Order 11 | |
| Primary Uses: | Not used commercially, detected in ambient atmospheric samples. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| 1-Nitropyrene | CAS Number 5522-43-0 | Review Order 7 | |
| Primary Uses: | Not used commercially, detected in ambient atmospheric samples and as a constituent of diesel and gasoline engine exhaust. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| 4-Nitropyrene | CAS Number 57835-92-4 | Review Order 8 | |
| Primary Uses: | Not used commercially, detected in ambient atmospheric samples. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
| Thiotepa | CAS Number 52-24-4 | Review Order 2 | |
| Primary Uses: | Used as a cytostatic agent in the treatment of lymphomas and a variety of solid tumors, such as breast and ovary. It has also been used at high doses in combination chemotherapy with cyclophosphamide in patients with refractory malignancies treated with autologous bone transplantation. | ||
| Nominated as: | Known to be a Human Carcinogen | ||
| 1,2,3-Trichloropropane | CAS Number 96-18-4 | Review Order 15 | |
| Primary Uses: | Used as a polymer crosslinking agent, paint and varnish remover, solvent and degreasing agent. It has been found as an impurity in certain nematicides and soil fumigants and has been detected in drinking and ground water in various parts of the United States. | ||
| Nominated as: | Reasonably Anticipated to be a Human Carcinogen | ||
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