Signal Transduction Program
Overview
This program supports fundamental research on the molecular and cellular substrates of neuronal signaling, the factors that influence the signaling process, and the mechanisms that underlie changes in signaling strength. Research supported by this program include studies of neurotransmitters, signaling cascades, and second messengers systems; studies of compartmentalization, targeting, and trafficking of signaling molecules; studies of pre- and post-synaptic proteins, neurotransmitter transporters, ion channels, and ion pumps; and studies of synaptic growth and synaptic plasticity.
Areas of Emphasis
- Identifying the key molecules and mechanisms that mediate changes in synaptic efficacy in the brain's inhibitory circuitry.
- Elucidating the mechanisms that underlie such key properties of psychoactive drug actions as desensitization, delayed effectiveness, and long-term efficacy.
- Identifying key protein-protein interactions associated with short and long term synaptic function and to contribute to the establishment of large-scale protein-protein interactions maps of the brain.
Contact
Chiiko Asanuma, Ph.D.
Program Chief
6001 Executive Boulevard, Room 7183, MSC 9641
301-443-5288, casanuma@mail.nih.gov
