Diabetes Prevention Program Outcomes Study

• What is DPPOS?
  
• DPPOS Background
  
• DPPOS Objectives
  
• DPPOS Clinical Centers

What Is DPPOS?

The Diabetes Prevention Program Outcomes Study is studying the long term effect of diet and exercise and the diabetes medication, metformin, on the delay of type 2 diabetes in participants of the Diabetes Prevention Program (DPP).

DPPOS Background

The DPPOS is designed as a follow-up study to the participants enrolled in the Diabetes Prevention Program (DPP). The DPP was a multi-center trial examining the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population due to the presence of impaired glucose tolerance (IGT). The DPP has ended early demonstrating that lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%. This group of participants is nearly 50% minority and represents the largest IGT population ever studied. Clinically important research questions remain that focus on 1)durability of the prior DPP intervention, 2) determination of the clinical course of precisely known new onset diabetes, in particular regarding CVD, CVD risk factors and atherosclerosis and microvascular disease, 3)close examination of these topics in men vs women and in minority populations.

DPPOS Objectives

Clinically important research questions remain that focus on 1)durability of the prior DPP intervention, 2) determination of the clinical course of precisely known new onset diabetes, in particular regarding CVD, CVD risk factors and atherosclerosis and microvascular disease, 3)close examination of these topics in men vs women and in minority populations.

DPPOS Clinical Centers

DPPOS is made up of the 26 Diabetes Prevention Program (DPP) clinical centers and one data coordinating center funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).