Fludeoxyglucose F18 Positron Emission Tomography Imaging In Assessing Patients Before and After Treatment for Locally Advanced Non-Small Cell Lung Cancer
A total of 250 patients (including at least 75 with stage IIB/IIIA disease and at least 75 with stage IIIB disease) will be accrued for this study within 2 years.
Relationship of survival to post-treatment peak standardized uptake value (SUV) as determined by the imaging institution
Relationship of survival to post-treatment max SUV as determined by the imaging institute
Relationship of local control to post-treatment peak and max SUV as determined by the imaging institution
Relationship of survival and of local control to pre-treatment peak and max SUV as determined by the imaging institution
Reliability between peak and max SUV measurements both pre- and post-treatment
Proportion of participants who are either upstaged or downstaged by positron emission tomography scan
Reliability between PET scan-defined response to therapy measurements
Correlation of Ki-67 expression with peak and max pre-treatment SUV
Association between Ki-67 expression and overall survival at 2 years
This is a diagnostic, multicenter study.
Before starting chemoradiotherapy, patients undergo baseline whole-body positron emission tomography (PET) imaging. Patients receive fludeoxyglucose F 18 (18FDG) IV followed 50-70 minutes later by PET imaging. Patients then receive concurrent definitive radiotherapy and chemotherapy. Patients enrolled in other treatment-oriented clinical trials receive therapy as per that trial. Other patients receive standard thoracic radiotherapy (dose ≥ 60 Gy) and standard chemotherapy comprising a platin (cisplatin or carboplatin) and a second non-platin, non-gemcitabine drug (etoposide, vinblastine, vinorelbine, paclitaxel, or docetaxel). Approximately 14 weeks after completion of chemoradiotherapy and adjuvant chemotherapy (if given), patients undergo post-treatment 18FDG-PET imaging.
Patients are followed every 3 months for 2 years and then every 6 months for at least 1 year.
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U.S.A. |
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Alabama |
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Birmingham |
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| Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham |
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| Clinical Trials Office - Lurleen Wallace Comprehensive Cancer | |
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Arizona |
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Scottsdale |
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| Scottsdale Medical Imaging, Limited |
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| Allison Irving | Ph: | 480-425-5000 ext. 5044 | | |
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California |
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Los Angeles |
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| USC/Norris Comprehensive Cancer Center and Hospital |
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| Clinical Trials Office - USC/Norris Comprehensive Cancer Center and Hospital | |
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Sacramento |
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| Radiological Associates of Sacramento Medical Group at Sutter Cancer Center |
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| Kim Vagharfard | Ph: | 916-454-6699 ext. 80383 | | |
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| Email:
vagharfardk@radiological.com |
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Connecticut |
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New Haven |
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| Hospital of Saint Raphael |
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| Clinical Trials Office - Hospital of Saint Raphael | |
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Florida |
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Boynton Beach |
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| Bethesda Comprehensive Cancer Care Center at Bethesda Memorial Hospital |
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| Clinical Trials Office - Bethesda Comprehensive Cancer Care Center | |
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Dearfield Beach |
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| North Broward Medical Center |
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| Clinical Trials Office - North Broward Medical Center | |
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Jacksonville |
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| Integrated Community Oncology Network at Baptist Cancer Institute |
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| Jan Peer | |
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Tallahassee |
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| Tallahassee Memorial Hospital |
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| Rowena Dimayuga | |
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Illinois |
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Chicago |
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| Rush Cancer Institute at Rush University Medical Center |
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| Clinical Trials Office - Rush Cancer Institute at Rush University Medical Center | |
| Email:
clinical_trials@rush.edu |
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Indiana |
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Anderson |
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| Saint John's Cancer Center at Saint John's Medical Center |
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| Patricia Farran, RN, OCN, CTR RA | |
| Email:
pafarran@sjhsnet.org |
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Goshen |
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| Center for Cancer Care at Goshen General Hospital |
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| Clinical Trials Office - Center for Cancer Care at Goshen General Hospital | |
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South Bend |
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| CCOP - Northern Indiana CR Consortium |
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| Virginia Bolin | |
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Maryland |
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Baltimore |
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| Greenebaum Cancer Center at University of Maryland Medical Center |
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| Clinical Trials Office - Greenebaum Cancer Center at University of Maryladn Medical Center | |
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Massachusetts |
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Boston |
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| Beth Israel Deaconess Medical Center |
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| Clinical Trials Office - Beth Israel Deaconess Medical Center | |
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| Dana-Farber Partners Cancer Care |
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| Jennifer Curry | |
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South Weymouth |
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| South Shore Hospital |
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| Kelly O'Neil | |
| Email:
koneil@shcpo.shields.com |
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Michigan |
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Detroit |
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| Josephine Ford Cancer Center at Henry Ford Hospital |
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| Karen Dziubek | Ph: | 313-916-9462 | | 888-734-5322 |
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Kalamazoo |
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| West Michigan Cancer Center |
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| Clinical Trials Office - West Michigan Cancer Center | |
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Royal Oak |
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| William Beaumont Hospital - Royal Oak Campus |
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| Clinical Trials Office - William Beaumont Hospital - Royal Oak Campus | |
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Missouri |
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St. Louis |
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| Mallinckrodt Institute of Radiology at Washington University Medical Center |
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| Clinical Trials Office - Mallinckrodt Institute of Radiology at Washington University Medical Center | |
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Nevada |
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Reno |
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| Renown Institute for Cancer at Renown Regional Medical Center |
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| Lynn Jarvis | Ph: | 775-982-5842 | | 866-559-0558 |
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| Email:
ljarvis@washoehealth.com |
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New Hampshire |
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Lebanon |
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| Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center |
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| Clinical Trials Office - Norris Cotton Cancer Center | |
| Email:
cancerhelp@dartmouth.edu |
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New Jersey |
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Teaneck |
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| Sister Patricia Lynch Regional Cancer Center at Holy Name Hospital |
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| Clinical Trials Office - Sister Patricia Lynch Regional Cancer Center at Holy Name Hospital | |
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Toms River |
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| J. Phillip Citta Regional Cancer Center at Community Medical Center |
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| Clinical Trials Office - J. Phillip Citta Regional Cancer Center at Community Medical Center | |
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Ohio |
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Akron |
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| McDowell Cancer Center at Akron General Medical Center |
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| Kim Surface | |
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Cleveland |
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| Cleveland Clinic Cancer Center at Fairview Hospital |
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| Clinical Trials Office - Cleveland Clinic Cancer Center at Fairview Hospital | |
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| Cleveland Clinic Taussig Cancer Center |
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| Clinical Trials Office - Cleveland Clinic Taussig Cancer Center | |
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Oklahoma |
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Oklahoma City |
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| Oklahoma University Cancer Institute |
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| Faraz Masood | |
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Oregon |
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Portland |
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| Oregon Health and Science University Cancer Institute |
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| Clinical Trials Office - Oregon Health and Science University Cancer Institute | |
| Email:
trials@ohsu.edu |
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Pennsylvania |
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Philadelphia |
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| Albert Einstein Cancer Center |
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| Sharon Byrne | |
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| Fox Chase Cancer Center - Philadelphia |
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| Clinical Trials Office - Fox Chase Cancer Center - Philadelphia | |
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| Kimmel Cancer Center at Thomas Jefferson University - Philadelphia |
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| Clinical Trials Office - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia | |
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Pittsburgh |
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| UPMC Cancer Centers |
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| Clinical Trials Office - UPMC Cancer Centers | |
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Wynnewood |
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| Lankenau Cancer Center at Lankenau Hospital |
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| Judith Fanelli | |
| Email:
fanellij@mlhs.org |
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Rhode Island |
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Providence |
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| Brown University School of Medicine |
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| Cindy Cobb | |
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| Roger Williams Medical Center |
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| Cindy Cobb | |
| Email:
ccobb@lifespan.org |
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South Carolina |
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Charleston |
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| Hollings Cancer Center at Medical University of South Carolina |
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| Clinical Trials Office - Hollings Cancer Center at Medical University of South Carolina | |
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Spartanburg |
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| Gibbs Regional Cancer Center at Spartanburg Regional Medical Center |
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| Clinical Trials Office - Gibbs Regional Cancer Center | |
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Tennessee |
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Nashville |
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| Vanderbilt-Ingram Cancer Center |
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| Clinical Trials Office - Vanderbilt-Ingram Cancer Center | |
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Texas |
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Dallas |
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| Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas |
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| Clinical Trials Office - Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas | Ph: | 866-460-4673; 214-648-7097 | | |
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Houston |
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| M. D. Anderson Cancer Center at University of Texas |
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| Clinical Trials Office - M. D. Anderson Cancer Center at the University of Texas | |
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Utah |
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Salt Lake City |
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| Huntsman Cancer Institute at University of Utah |
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| Clinical Trials Office - Huntsman Cancer Institute at University of Utah | |
| Email:
clinical.trials@hci.utah.edu |
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Virginia |
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Richmond |
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| Bon Secours Cancer Institute at St. Mary's Hospital |
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| Ann Kaplan | |
| Email:
ann_kaplan@bshsi.com |
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Wisconsin |
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Madison |
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| University of Wisconsin Paul P. Carbone Comprehensive Cancer Center |
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| Clinical Trials Office - University of Wisconsin Paul P. Carbone Comprehensive Cancer Center | |
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Waukesha |
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| Waukesha Memorial Hospital Regional Cancer Center |
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| Clinical Trials Office - Waukesha Memorial Hospital Regional Cancer Center | |
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Canada |
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Alberta |
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Calgary |
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| Tom Baker Cancer Centre - Calgary |
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| Pina Sjoblom | |
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Ontario |
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Kitchner |
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| Grand River Regional Cancer Centre at Grand River Hospital |
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| Carla Girolametto | |
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Republic of Korea |
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Goyang |
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| National Cancer Center - Korea |
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| Hyang Kang | |
| Email:
nccrtog@ncc.re.kr |
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