Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
13 WEEK SUBCHRONIC
Facility: Southern Research Institute
Chemical CAS #: 25152-84-5
Lock Date: 07/30/97
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Hepatodiaphragmatic Nodule 4 (40%)
Infiltration Cellular, Mixed Cell 1 (10%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (9) (10) (10) (10)
Edema 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%) 2 (20%) 9 (90%)
Epithelium, Degeneration 2 (20%) 10 (100%)
Epithelium, Hyperplasia 6 (60%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%)
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (1) (1) (10)
Cyst 1 (10%) 1 (100%) 1 (100%)
Uterus (10) (3) (10)
Hydrometra 4 (40%) 3 (100%) 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (9)
Hemorrhage 2 (22%) 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10) (10) (10) (10)
Exudate 1 (10%) 1 (10%)
Olfactory Epithelium, Atrophy 1 (10%)
Olfactory Epithelium, Necrosis 1 (10%)
Respiratory Epithelium, Inflammation 1 (10%)
Respiratory Epithelium, Metaplasia, Squamous 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (10) (10)
Erosion, Focal 1 (10%)
Inflammation, Chronic Active 1 (10%)
Liver (10) (10)
Hepatodiaphragmatic Nodule 1 (10%)
Infiltration Cellular, Mixed Cell 1 (10%) 1 (10%)
Stomach, Forestomach (10) (10) (10) (10) (10) (10)
Edema 2 (20%)
Inflammation, Chronic Active 2 (20%) 2 (20%)
Epithelium, Degeneration 1 (10%) 5 (50%)
Epithelium, Hyperplasia 4 (40%) 6 (60%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 3 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Pituitary Gland (10) (10)
Pars Distalis, Cyst 1 (10%)
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10)
Hemorrhage 7 (70%) 4 (40%)
Lymph Node, Mesenteric (10) (10)
Hemorrhage 1 (10%)
Thymus (10) (1) (9)
Hemorrhage 1 (100%) 2 (22%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (1) (10)
Inflammation, Chronic 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Hemorrhage 4 (40%) 3 (30%)
Infiltration Cellular, Histiocyte 1 (10%)
Metaplasia, Osseous 1 (10%)
Nose (10) (10) (10) (9) (10) (10)
Exudate 2 (20%) 6 (60%)
Inflammation, Chronic 1 (10%) 1 (10%)
Olfactory Epithelium, Atrophy 1 (11%) 1 (10%) 4 (40%)
Olfactory Epithelium, Necrosis 1 (11%)
Respiratory Epithelium, Hyperplasia 1 (10%)
Sinus, Exudate 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
NTP Experiment-Test: 93022-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 2,4-DECADIENAL Date: 09/08/99
Route: GAVAGE Time: 13:48:41
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 50 100 200 400 800
MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY MG/KG/DY
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Turbinate, Osteofibrosis 1 (11%) 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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