Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
Final#1/Rats
Facility: Battelle Columbus Laboratory
Chemical CAS #: 118-74-1
Lock Date: 01/17/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 MG/KG 0.03 0.1 0.3 1.0 3.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 10 9 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%) 1 (10%) 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%) 1 (10%)
Infiltration Cellular, Mixed Cell 8 (80%) 6 (60%) 5 (50%) 9 (90%) 6 (60%) 9 (90%)
Oral Mucosa (3)
Gingival, Inflammation 3 (100%)
Pancreas (10) (1)
Acinus, Atrophy 1 (10%)
Tongue (10) (1)
Vein, Dysplasia 1 (10%)
Tooth (10) (10) (10) (10) (10) (10)
Incisor, Degeneration 5 (50%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10) (10) (10) (9)
Ultimobranchial Cyst 1 (10%) 3 (30%) 3 (30%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 MG/KG 0.03 0.1 0.3 1.0 3.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (1)
Corpus Luteum, Cyst 2 (20%)
Uterus (10) (1)
Endometrium, Hyperplasia, Cystic 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 4 (40%) 4 (40%) 3 (30%) 4 (40%) 6 (60%)
Pigmentation, Hemosiderin 10 (100%) 8 (80%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Thymus (10) (10) (10) (10) (10) (10)
Atrophy 1 (10%)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10) (10) (10)
Hyperplasia 2 (20%) 2 (20%) 1 (10%) 2 (20%) 2 (20%)
Skin (10) (10) (9) (10) (10) (9)
Hair Follicle, Inflammation, Chronic Active,
Focal 1 (11%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Inflammation, Chronic 3 (30%) 1 (10%) 1 (10%) 2 (20%) 7 (70%) 8 (80%)
Alveolar Epithelium, Hyperplasia 2 (20%)
Alveolus, Inflammation, Suppurative 1 (10%)
Bronchiole, Hyperplasia 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 MG/KG 0.03 0.1 0.3 1.0 3.0
MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Perivascular, Infiltration Cellular,
Polymorphonuclear 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1)
Nephropathy 7 (70%) 1 (100%)
Cortex, Mineralization 1 (100%)
Papilla, Mineralization 4 (40%) 1 (100%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 10.0 25.0
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Infiltration Cellular, Mixed Cell 10 (100%) 10 (100%)
Vacuolization Cytoplasmic, Focal 2 (20%)
Hepatocyte, Hypertrophy 9 (90%) 10 (100%)
Tooth (10) (10)
Incisor, Degeneration 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10)
Ultimobranchial Cyst 2 (20%) 3 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10)
Corpus Luteum, Cyst 1 (10%)
Uterus (10)
Endometrium, Hyperplasia, Cystic 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 10.0 25.0
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Hematopoietic Cell Proliferation 5 (50%) 6 (60%)
Hyperplasia, Lymphoid 6 (60%) 8 (80%)
Pigmentation, Hemosiderin 8 (80%) 9 (90%)
Thymus (10) (10)
Atrophy 3 (30%)
Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10)
Hyperplasia 3 (30%) 10 (100%)
Skin (10) (10)
Inflammation, Suppurative 9 (90%)
Ulcer 7 (70%)
Dermis, Infiltration Cellular, Mononuclear
Cell 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Inflammation, Chronic 10 (100%) 10 (100%)
Bronchiole, Hyperplasia 2 (20%)
Interstitium, Fibrosis, Focal 1 (10%)
Trachea (1)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 98004-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY HEXACHLOROBENZENE Date: 10/23/02
Route: GAVAGE Time: 10:18:30
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 10.0 25.0
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Nephropathy 9 (90%)
Papilla, Mineralization 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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