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Found 22 studies with search of:   "Severe Combined Immunodeficiency" OR "adenosine deaminase deficiency"
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Rank Status Study
1 Recruiting MND-ADA Transduction of CD34+ Cells From Children With Adenosine Deaminase (ADA)-Deficient Severe Combined Immunodeficiency (SCID)
Condition: Severe Combined Immunodeficiency
Intervention: Biological: ADA gene transfer
2 Completed Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome
Condition: Severe Combined Immunodeficiency
Interventions: Procedure: Stem cell transplant;   Drug: Filgrastim, Alemtuzumab;   Device: Miltenyi CliniMACS
3 Recruiting Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1
Conditions: Growth Failure;   X-Linked Severe Combined Immunodeficiency (XSCID);   Growth Hormone Resistence
Interventions: Drug: Increlex;   Procedure: Arginine Provocation Test;   Procedure: Clonidine Provocation Test;   Procedure: IGF-1 Generation Test;   Drug: IVIG;   Procedure: Haplo-Identical Bone Marrow Transplant
4 Recruiting Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency
Condition: Severe Combined Immunodeficiency Syndrome
Intervention: Drug: CD34+ cells transduced with ADA retrovir
5 Completed Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study
Condition: Severe Combined Immunodeficiency
Interventions: Drug: ADA PBSC;   Drug: ADA Umbilical Cord Blood Cells;   Drug: Transduced Lymphocytes
6 Recruiting Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)
Condition: Severe Combined Immunodeficiency
Intervention: Drug: Gene-Transduced Autologous CD34+ Stem Cells
7 Recruiting Pilot Study of Allogeneic Bone Marrow Transplantation Plus Cyclosporine and Mycophenolate Mofetil to Induce Mixed Hematopoietic Chimerism in Patients With Primary T-Cell Immunodeficiency Disorders
Conditions: Purine-Pyrimidine Metabolism, Inborn Errors;   Wiskott-Aldrich Syndrome;   Bare Lymphocyte Syndrome;   Lymphopenia;   Job's Syndrome;   DiGeorge Syndrome;   Omenn Syndrome;   X-Linked Hyper IgM Syndrome;   Severe Combined Immunodeficiency;   Immunologic Deficiency Syndromes
Interventions: Drug: Cyclosporine;   Drug: Mycophenolate mofetil
8 Completed Influences on Female Adolescents' Decisions Regarding Testing for Carrier Status of XSCID
Condition: Severe Combined Immunodeficiency
Intervention:
9 Active, not recruiting Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
Conditions: Immunologic Deficiency Syndromes;   Chediak-Higashi Syndrome;   Common Variable Immunodeficiency;   Graft Versus Host Disease;   X-Linked Lymphoproliferative Syndrome;   Familial Erythrophagocytic Lymphohistiocytosis;   Hemophagocytic Lymphohistiocytosis;   X-Linked Agammaglobulinemia;   Wiskott-Aldrich Syndrome;   Chronic Granulomatous Disease;   X-Linked Hyper IgM Syndrome;   Severe Combined Immunodeficiency;   Leukocyte Adhesion Deficiency Syndrome;   Virus-Associated Hemophagocytic Syndrome
Interventions: Drug: anti-thymocyte globulin;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: etoposide;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: prednisone;   Procedure: Allogeneic Bone Marrow Transplantation
10 Recruiting Anti-CD45 Monoclonal Antibody, Alemtuzumab, and Fludarabine Followed By Donor Stem Cell Transplant in Treating Children With Severe Combined Immunodeficiency Disease or Other Primary Immunodeficiency Disorder
Condition: Precancerous/Nonmalignant Condition
Interventions: Drug: alemtuzumab;   Drug: anti-CD45 monoclonal antibody;   Drug: fludarabine phosphate;   Procedure: allogeneic hematopoietic stem cell transplantation
11 Completed Cord Blood Stem Cell Transplantation Study (COBLT)
Conditions: Anemia, Aplastic;   Fanconi Anemia;   Hematologic Diseases;   Leukemia;   Neoplasms;   Severe Combined Immunodeficiency;   Hematopoietic Stem Cell Transplantation;   Myelodysplastic Syndromes
Intervention: Procedure: stem cell transplantation
12 Recruiting Use of G-CSF to Obtain Blood Cell Precursors
Conditions: Chronic Granulomatous Disease;   Healthy;   Immunologic Disease;   Leukocyte Adhesion Deficiency Syndrome;   Severe Combined Immunodeficiency
Intervention:
13 Recruiting IMM 0212: Busulfan With Fludarabine and Antithymocyte Globulin as Preparative Therapy for Hematopoietic Stem Cell Transplant for the Treatment of Severe Congenital T-Cell Immunodeficiency
Conditions: T-Cell Immune Deficiency Diseases;   Severe Combined Immunodeficiency
Intervention: Drug: Busulfan, Fludarabine and ATG
14 Completed Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients
Conditions: Immunologic Deficiency Syndrome;   Agammaglobulinemia;   Severe Combined Immunodeficiency;   Wiskott-Aldrich Syndrome;   Common Variable Immunodeficiency
Interventions: Drug: Immune Globulin Intravenous [Human], 10% Caprylate/Chromatography Purified;   Drug: Dextrose, 5% in Water
15 Recruiting Genetic Analysis of Immune Disorders
Conditions: Healthy;   Immunologic Deficiency Syndrome;   Job's Syndrome;   Severe Combined Immunodeficiency
Intervention:
16 Recruiting Genetic Basis of Immunodeficiency
Condition: Severe Combined Immunodeficiency
Intervention:
17 Recruiting Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked Products
Conditions: Severe Combined Immunodeficiency;   Malignancy, Hematologic;   Neuroblastoma;   Neoplasm;   Mucopolysaccharidosis I
Intervention: Procedure: Venipuncture
18 Completed ADA Gene Transfer Into Hematopoietic Stem/Progenitor Cells for the Treatment of ADA-SCID
Condition: Severe Combined Immunodeficiency
Intervention: Genetic: Gene transduced CD34+ cells
19 Completed Gene Therapy for ADA-SCID
Condition: Severe Combined Immunodeficiency Syndrome
Intervention: Genetic: gene transduced PBL and/or gene transduced HSC
20 Recruiting Allogeneic SCT Of Pts With SCID And Other Primary Immunodeficiency Disorders
Condition: Immunodeficiency
Interventions: Drug: Campath -1H;   Drug: Fludarabine;   Biological: Anti-CD45;   Procedure: Stem cell infusion

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