SCOTT P. LAYNE, MD
Professor
UCLA School of Public Health
Member
California NanoSystems Institute


PO Box 951772
650 Charles E. Young Drive South
Los Angeles, CA 90095-1772 310-825-8193 TEL
310-206-6039 FAX
scott.layne@ucla.edu EMAIL
OCTOBER 2008

layne_small.jpg

SCOTT P. LAYNE, MD, is a Professor of Epidemiology and of Environmental Healh Sciences at the University of California Los Angeles (UCLA) School of Public Health (SPH).  He is known for cross-disciplinary work involving biology, physics, and policy-related issues, and has authored over 45 publications, including three U.S. patents on methods to access and operate high-throughput laboratories.

Dr. Layne is the Principal Investigator of the Center for Rapid Influenza Surveillance and Response (CRISAR), which is one of six NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS).  With $20.1 million over five years, CRISAR will undertake national and international surveillance on animal and human derived influenza strains, and will actively contribute to NIAID's Pandemic Public Health Research Response Plan.  Participating institutions include UCLA, University of California Davis (UCD), University of Alaska Fairbanks (UAF), Wildlife Conservation Society (WCS), and Los Alamos National Laboratory (LANL).

Dr. Layne is also leading the development of the UCLA High Speed, High Volume Laboratory Network for Infectious Diseases in collaboration with Los Alamos (LANL). The program, funded by congressionally directed Department of Defense investments and a grant from the California Office of Homeland Security (press release) that amount to $30 million, will improve the nation's ability to make rapid and critically important decisions to save lives in the event of bioterror attacks or infectious disease outbreaks.  The laboratory will enable public health experts to track diseases in near real time and dramatically shorten the time needed to produce effective vaccines.  The program will expedite widespread collection and testing of influenza samples within a few days of collection and thereby guide emergency outbreak control efforts.  The laboratory will test and analyze many more viruses than are currently examined by state laboratories and enhance capacity should laboratories be overloaded.

Dr. Layne is an editor of Firepower in the Lab: Automation in the Fight Against Infectious Diseases and Bioterrorism (Joseph Henry Press, 2001) and also of Jane's Chem-Bio Handbook, 2nd and 3rd editions.  In 1988, he organized the workshop A National Effort to Model AIDS Epidemiology for the Office of Science and Technology Policy (OSTP) and oversaw the publication of a White House Report that influenced AIDS research priorities in the United States.  In 1999, he also organized the meeting Automation in Threat Reduction and Infectious Disease Research: Needs and New Direction under the auspices of the Institute of Medicine and National Academy of Engineering.  In August 2008, he was appointed to be a Member of the National Biosurveillance Advisory Subcommittee (roster) as authorized under Homeland Security Presidential Directive/HSPD-21 (White House).

Dr. Layne teaches graduate level courses at UCLA on infectious diseases (EPI 220) and public health responses to bioterrorism and pandemic influenza (EPI 226).  He is also an instructor on bioterrorism preparedness for the U.S. Department of Homeland Security and lectures throughout the country in this capacity.

Dr. Layne received a Bachelor of Arts in chemistry from DePauw University in 1976 and Doctor of Medicine from Case Western Reserve University in 1980.  He is board certified in internal medicine and infectious diseases, with a fellowship in adult infectious diseases.  He served as a postdoctoral fellow and staff member at the Los Alamos National Laboratory (LANL) from 1982-1986, as a physicist at the Lawrence Livermore National Laboratory (LLNL) from 1986-1992, and maintains guest scientist status at LANL.


COURSES

- Fall 2008: EPI 220 (link) UPDATED
    Principles of Infectious Disease Epidemiology

- Winter 2008

- Spring 2008: EPI/EEB M226 (link)
     Global Health Measures for Biological Emergencies

ACTIVITIES

- NIAID Center of Excellence for Influenza Research and Surveillance (link)

- NIAID Center of Excellence for Influenza: News (link)

- Identifying, Forecasting and Evaluating Infectious Disease Threats (pdf)

- TradelineInc. Conference (link)

- $9 Million for High-Speed, High-Volume Lab (press release)

- Avian Influenza UCOP (link)

- Testimony to California Assembly, November 2005 (download)

- High-Throughput Laboratory Network (link)

BIO and CV (download)

PIC (download)

WHITE PAPER Release1.0 (pdf)
This white paper summarizes our activities, progress to date, and work to come on the High Speed, High Volume Laboratory Network for Infectious Diseases and Center for Rapid Influenza Surveillance and Research at the University of California Los Angeles (UCLA).  It emphasizes that implementing near real-time, global and (what aspires to) transparent surveillance of infectious diseases is an essential next step for human health and security.  It also explains how our efforts will enable this next step, first at one laboratory site and then at multiple networked sites.  Cited on-line materials and references at the end provide additional information.


SELECTED PUBLICATIONS

- Nature Reviews Microbiology 2007 (download)

- Emerging Infectious Diseases 2006 (download)

- Journal Association Laboratory Automation 2003 (download)

- Biosecurity and Bioterrorism 2003 (download)

- Los Angeles Times 2002 (download)

- Institute of Medicine 2002 (download)

- Molecular Diagnosis 2001 (download)

- Science 2001 (download)

- PNAS 1999 (download)

- Nature Biotechnology 1998 (download)

- U.S. Patent 5,841,975 1998 (download)

- Virology 1992 (download)

- Journal Virology 1991 (download)

- Nature 1990 (download)

- PNAS 1989 (download)

- Nature 1988 (download)

REPORTS

- Office of Science and Technology Policy 1988 (download)

SELECTED PRESENTATIONS

- CEIRS Kick Off Meeting 2007 (download)

- AAAS Annual Meeting 2002 (download)

COLLOQUIUM ORGANIZER

Automation in Threat Reduction and Infectious Disease Research: Needs and New Directions was held at the National Academy of Sciences on April 29 - 30, 1999. The colloquium put scientific needs in the drivers seat and then considered pivotal roles for technology in the following areas.

(a) Fighting deadly infectious diseases such as influenza A, multi-drug resistant tuberculosis, and HIV/AIDS.

(b) Ensuring safe food by reducing risks, detecting pathogens and toxins, and rapidly investigating outbreaks.

(c) Mitigating bioterrorism and biowarfare by preventing attacks, characterizing agents, and minimizing aftermaths.

(d) Facilitating work on human genetics and molecular medicine especially in predicting cancers, diagnosing diseases, and tailoring medications.

Organizers: Kumar Patel; Tony Beugelsdijk; and Scott Layne. Co-sponsors: Association for Laboratory Automation; Centers for Disease Control and Prevention; Department of Health and Human Resources, Office of Emergency Preparedness; Los Alamos National Laboratory; Institute of Medicine; National Academy of Engineering; and University of California, Los Angeles.

Book: The colloquium proceedings were published by the National Academy Press / Joseph Henry Press in 2001 (http://books.nap.edu/catalog/9749.html).

NEWS

- Nature 2001 (download)

- Emerging Infectious Diseases 1999 (download)

- Nature 1999 (download)

- ASM News 1999 (download #1)

- ASM News 1999 (download #2)