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This section studies the mechanism and regulation of intracellular trafficking, biosynthesis and processing of neuropeptides, peptide hormones and other proteins found in the regulated secretory pathway of neuroendocrine cells. Current studies focus on the identification of pro-hormone sorting signals and their receptors as a mechanism of targeting these proteins to the regulated secretory pathway, as well as the role of chromogranins, a major secretory protein in endocrine cells, in granule biogenesis. Knock-out mouse models are being used to study hormone trafficking diseases. In addition, proteolytic enzymes involved in the processing of pro- neuropeptides and prohormones are being studied, with specific emphasis on PC1 and PC2.
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