Retha Newbold, M.S., CT, is a staff scientist/developmental biologist in the Toxicology Branch at the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, North Carolina. She serves as a NTP discipline expert in Reproductive and Developmental Toxicology. Her recent research is focused on investigating the mechanisms of environmental endocrine disrupting chemicals and drug effects on development, reproduction and obesity. Prior to joining the Toxicology Branch, she was head of the Developmental Endocrinology and Endocrine Disruptor Section in the Laboratory of Molecular Toxicology at NIEHS. She has been actively researching environmental estrogens at NIEHS for over 30 years. Some of her most significant work has been the development of an experimental animal model to study the adverse effects of environmental estrogens when exposure occurs during critical periods of differentiation; she uses diethylstilbestrol (DES) as a protype estrogen. The establishment of this animal model has provided the framework on which many of her subsequent mechanistic studies have been based and for her continuing interest in the field termed “the developmental basis of adult disease.”
Newbold has received numerous scientific awards including The Distinguished Service Award from DES Action USA and was recognized by NIH with the Harvey J. Bullock, Jr. Award for EEO Achievement. She has served on numerous national and international advisory committees (EPA, FDA, NCI, OWH, WHO, OECD, ICCVAM) dealing with reproductive and developmental toxicology, and endocrine disruption.
Newbold is a member of a number of learned societies including the American Association for Cancer Research, The Endocrine Society, Society for the Study of Reproduction, Society of Toxicology and The American Society for Clinical Pathologists. She serves as a reviewer for numerous scientific journals including Cancer Research, Biology of Reproduction, Environmental Health Perspectives, Reproductive Toxicology, Endocrinology, Developmental Biology, Lancet, Science and others. She is the author or co-author of over 200 peer-reviewed publications and book chapters plus numerous regulatory study reports.
Selected Publications
Newbold, R.R., Bullock, B.C. and McLachlan, J.A. (1990) Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis. Cancer Research, 50, 7677-7681. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/2174729?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R. (1995) Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmnetal estrogens. Environmental Health Perspectives, 103, 83-87. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/8593881?ordinalpos=26&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R. and McLachlan, J.A. (1996) Transplacental hormonal carcinogenesis: diethylstilbestrol as an example. In Huff, J., Boyd, J. and Barrett, J.C. (eds.), Cellular and Molecular Mechanisms of Hormonal Carcinogenesis: Environmental Influences. Wiley-Liss, New York, pp. 131-147. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/8778794?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Jefferson, W.N., Padilla-Burgos, E. and Bullock, B.C. (1997) Uterine carcinoma in mice treated neonatally with tamoxifen. Carcinogenesis, 18, 2293-2298. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/9450472?ordinalpos=68&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R. and Liehr, J. (2000) Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Cancer Research, 60, 235-237. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/10667565?ordinalpos=60&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Jefferson, W.N., Padilla-Banks, E., Walker, V.R. and Pena, D.S. (2001) Cell response endpoints enhance sensitivity of the immature mouse uterotropic assay. Reprod Toxicol, 15, 245-52. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11390168?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Banks, E.P., Bullock, B. and Jefferson, W.N. (2001) Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res, 61, 4325-8. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/11389053?ordinalpos=46&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R. (2001) Models for endocrine cancer: uterine carcinoma as an example. In Hair, J. (ed.), Cancer Handbook. Macmillian Press.
Newbold, R. (2001) Effects of developmental exposure to diethylstilbestrol (DES) in rodents: Clues for other environmental estrogens. In: APMIS, vol. 109, pp. S261-272.
Newbold, R.R., Moore, A.B. and Dixon, D. (2002) Characterization of uterine leiomyomas in CD-1 mice following developmental exposure to diethylstilbestrol (DES). Toxicol Pathol, 30, 611-6. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/12371671?ordinalpos=30&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R. (2004) Lessons Learned from Perinatal Exposure to Diethylstilbestrol (DES). Toxicology and Applied Pharmacology, 199, 142-150. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15313586?ordinalpos=24&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Padilla-Banks, E., Snyder, R.J. and Jefferson, W.N. (2005) Developmental exposure to estrogenic compounds and obesity. Birth Defects Res A Clin Mol Teratol, 73, 478-80. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15959888?ordinalpos=19&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Padilla-Banks, E. and Jefferson, W.N. (2006) Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology, 147, S11-7. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16690809?ordinalpos=16&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Padilla-Banks, E., Snyder, R.J., Phillips, T.M. and Jefferson, W.N. (2007) Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod Toxicol, 23, 290-6. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17321108?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Jefferson, W.N. and Padilla-Banks, E. (2007) Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol, 24, 253-8. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17804194?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Newbold, R.R., Padilla-Banks, E., Jefferson, W.N. and Heindel, J.J. (2008) Effects of endocrine disruptors on obesity. Int J Androl, 31, 201-8. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18315718?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
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