Bethea HN, Xu D, Liu J, Pedersen LC. Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis. Proceedings of the National Academy of Sciences of the United States of America 105(48):18724-18729 (2008). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=19022906)
Ullah H, Scappini EL, Moon AF, Williams LV, Armstrong DL, Pedersen LC. Structure of a signal transduction regulator, RACK1, from arabidopsis thaliana. Protein science : a publication of the Protein Society, 17(10):1771-1780 (2008). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18715992)
Lin P, Batra VK, Pedersen LC, Beard WA, Wilson SH, Pedersen LG. Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase beta. Proc Natl Acad Sci USA, 105:5670-5674 (2008).
[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18391201)
Batra VK, Beard WA, Shock DD, PEDERSEN LC, Wilson SH. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell 30(3):315-324 (2008). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18471977)
Xu D, Moon AF, Song D, PEDERSEN LC, Liu J. Engineering sulfotransferases to modify heparan sulfate. Nature chemical biology (2008) 4(3):200-202. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18223645)
Moon AF, Garcia-Diaz M, Batra VK, Beard WA, Bebenek K, Kunkel TA, Wilson SH, PEDERSEN LC. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair 6(12):1709-1725 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17631059)
Liu, J. & PEDERSEN, L.C. Anticoagulant heparan sulfate: structural specificity and biosynthesis. Appl Microbiol Biotechnol, 74:263-272 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17131147)
Xu, D., Song, D., PEDERSEN, L.C. & Liu, J. Mutational study of heparan sulfate 2-O-sulfotransferase and chondroitin sulfate 2-O-sulfotransferase. J Biol Chem, 282:8356-8367 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17227754)
Ghosh, M., Meiss, G., Pingoud, A., London, R.E. & PEDERSEN, L.C. The nuclease A-inhibitor complex is characterized by a novel metal ion bridge. J Biol Chem, 282:5682-5690 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17138564)
Sucato, C.A., Upton, T.G., Kashemirov, B.A., Batra, V.K., Martinek, V., Xiang, Y., Beard, W.A., PEDERSEN, L.C., Wilson, S.H., McKenna, C.E., Florian, J., Warshel, A. & Goodman, M.F. Modifying the beta,gamma Leaving-Group Bridging Oxygen Alters Nucleotide Incorporation Efficiency, Fidelity, and the Catalytic mechanism of DNA polymerase beta. Biochemistry, 42:461-471 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17209556)
Moon, A.F., Garcia-Diaz, M., Bebenek, K., Davis, B.J. Zhong, X., Ramsden, D.A., Kunkel, T.A. & PEDERSEN, L.C. Structural insight into substrate specificity of DNA polymerase mu. Nat Struct Mol Biol, 14:45-53 (2007). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17159995)
Kirby, T.W., Harvey, S., DeRose, E.F., Chalov, S., Chikova, A., Perrino, F.W., Schaaper, R.M., London, R.E. & PEDERSEN, L.C. Structure of the Escherichia coli DNA Polymerase III epsilon-Hot proofreading complex. J Biol Chem, 281:38466:38471 (2006). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16973612)
Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., PEDERSEN, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M. & Wilson, S.H. Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc Natl Acad Sci USA, 103:17231-17236 (2006). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17079493)
Lin, P., PEDERSEN, L.C., Batra, V.K., Beard, W.A., Wilson, S.H. & Pedersen, L.G. Energy analysis of chemistry for correct insertion by DNA polymerase beta. Proc Natl Acad Sci USA, 103:13294-13299 (2006). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16938895)
Picher, A.J., Garcia-Diaz, M., Bebenek, K., PEDERSEN, L.C., Kunkel, T.A. & Blanco, L. Promiscuous mismatch extension by human DNA polymerase lambda. Nucleic Acids Research, 34:3259-3266 (2006). [Abstract](#)
Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., PEDERSEN, L.C. & Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure, 14:757-766 (2006). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16615916)
Garcia-Diaz, M., Bebenek, K., Krahn, J.M., PEDERSEN, L.C. & Kunkel, T.A. Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell, 124:331-342 (2006). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16439207)
Chen, J., Avci, F.Y., Munoz, E.M., McDowell, L.M., Chen, M., PEDERSEN, L.C., Zhang, L., Linhardt, R.J. & Liu, J. Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem, 280:42817-42825 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16260789)
Garcia-Diaz, M., Bebenek, K., Gao, G. PEDERSEN, L.C., London, R.E. & Kunkel, T.A. Structure-function studies of DNA polymerase lambda. DNA Repair, 4:1358-1367 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16213194)
Prasad, Rajendra, Batra, V.K., Yang, X., Krahn, J.M., PEDERSEN, L.C., Beard, W.A. & Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair, 4:1347-1357 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16172026)
Ghosh, M., Meiss, M., Pingoud, A., London, R.E. & PEDERSEN, L.C. Structural insight into the mechanism of Nuclease A, a ββα metal nuclease from Anabaena. J Biol Chem, 280:27990-7 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15897201)
Batra, V.K., Beard, W.A., Shock, D.D., PEDERSEN, L.C. & Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure, 13:1225-1233 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16084394)
Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A. & PEDERSEN, L.C. A closed conformation for the Pol lambda catalytic cycle. Nat Struct Mol Biol, 12:97-98 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15608652)
Ueda, A., Matsui, K., Yamamoto, Y. PEDERSEN, L.C., Sueyoshi, T. & Negishi, M. Thr 176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily-members PXR and VDR. Biochem. J., 388:623-630 (2005). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15610065)
Moon, A.F., Edavettal, S.C., Krahn, J.M., Munoz, E.M., Negishi, M., Linhardt, R.J., Liu, J. & PEDERSEN, L.C. Structural analysis of the sulfotransferase (3-O-sulfotransferase isoform 3) involved in the biosynthesis of an entry receptor for herpes simplex virus 1. J Biol Chem, 279:45185-93 (2004). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15304505)
Edavettal, S.C., Lee, K.A., Negishi, M., Linhardt, R.J., Liu, J., PEDERSEN, L.C. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase Isoform 1. J Biol Chem, 279:25789-97 (2004). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15060080)
Edavettal, S.C., Carrick, K., Shah, R.R., PEDERSEN, L.C., Tropsha, A., Pope, R.M. & Liu, J. A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. Biochemistry, 43:4680-8 (2004). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15096036)
Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Blanco, L., Kunkel, T.A. & PEDERSEN, L.C. A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology. Mol Cell, 13:561-72 (2004). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14992725)
Inoue, K., Sobhany, M., Transue, T.R., Oguma, K., PEDERSEN, L.C. & Negishi, M. Structural analysis by X-ray crystallography and calorimetry of a haemagglutinin component (HA1) of the progenitor toxin from Clostridium botulinum. Microbiology, 149:3361-70 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14663070)
Lee, K.A., Fuda, H., Lee, Y.C., Negishi, M., Strott, C.A. & PEDERSEN, L.C. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and PAP: rationale for specificity differences between prototypical SULT2A1 and the SULT2B1 isoforms. J Biol Chem, 278:44593-9 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12923182)
Shevtsov, S., Petrotchenko, E.V., PEDERSEN, L.C. & Negishi, M. Crystallographic analysis of a hydroxylated polychlorinated biphenyl (OH-PCB) bound to the catalytic estrogen binding site of human estrogen sulfotransferase. Environ Health Perspect, 111: 884-8 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12782487)
PEDERSEN, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K. & Negishi, M. Crystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis. J Biol Chem, 278:14420-8 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12562774)
Mueller, S.O., Hall, J.M., Swope, D.L., PEDERSEN, L.C. & Korach, K.S. Molecular determinants of the stereoselectivity of agonist activity of estrogen receptors (ER) alpha and beta. J Biol Chem, 278:12255-62 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12547836)
Gorokhov, A., Negishi, M., Johnson, E.F., PEDERSEN, L.C., Perera, L., Darden, T.A. & Pedersen, L.G. Explicit water near the catalytic I helix Thr in the predicted solution structure of CYP2A4. Biophys J, 84:57-68 (2003). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12524265)
PEDERSEN, L.C., Petrotchenko, E., Shevtsov, S. & Negishi, M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem, 277:17928-32 (2002). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11884392)
PEDERSEN, L.C., Darden, T.A. & Negishi, M. Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA. J Biol Chem, 277:21869-73 (2002). [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11950836)
Tone Y, Pedersen LC, Yamamoto T, Izumikawa T, Kitagawa H, Nishihara J, Tamura J, Negishi M, Sugahara K. 2-O-Phosphorylation of xylose and 6-O-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis. J Biol Chem, 283:16801-16807 (2008).
[Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18400750)
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