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Grace E. Kissling, Ph.D.

Biostatistics Branch

Grace E. Kissling, Ph.D.
Grace E. Kissling, Ph.D.
Staff Scientist

Tel (919) 541-1756
Fax (919) 541-4311

Curriculum Vitae (kissling-cv.pdf)  Download Adobe Reader
P.O. Box 12233
Mail Drop A3-03
Research Triangle Park, North Carolina 27709
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Grace E. Kissling’s primary responsibilities involve providing statistical advice and assistance for the toxicology and carcinogenicity studies carried out by the National Toxicology Program and experimental studies carried out by NIEHS researchers. She collaborates on research at all stages: study design, statistical analysis and interpretation.

Selected Publications

  1. Stout MD, Kissling GE, Suárez FA, Malarkey DE, Herbert RA, Bucher JR. Influence of helicobacter hepaticus infection and diet on the chronic toxicity and carcinogenicity of triethanolamine in B6C3F1 mice. Toxicologic pathology 2008; 36(6):783-794. [Abstract] ( Exit NIEHS
  2. Nwosu VC, Kissling GE, Trempus CS, Honeycutt H, French JE.  Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways. Toxicology and Applied Pharmacology 2004; 196(1):37-46. [Abstract] ( Exit NIEHS
  3. Ghanayem BI, Witt KL, El-Hadri L, Hoffler U, Kissling GE, Shelby MD, Bishop JB.  Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect. Biology of Reproduction 2005; 72:157-163. [Abstract] ( Exit NIEHS
  4. Bebenik A, Carver GT, Kadyrov FA, Kissling GE, Drake JW.  Processivity clamp gp45 and ssDNA-binding-protein gp32 modulate the fidelity of bacteriophage RB69 DNA polymerase in a sequence-specific manner, sometimes enhancing and sometimes compromising accuracy.  Genetics 2005; 169:1815-1824. [Abstract] ( Exit NIEHS
  5. Salo PM, Xia J, Johnson CA, Li Y, Kissling GE, Avol EL, Liu C, London SJ.  Respiratory symptoms in relation to residential coal burning and environmental tobacco smoke among early adolescents in Wuhan, China: a cross-sectional study. Environmental Health 2004; 3:14. [Abstract] ( Exit NIEHS
  6. Nyska A, Yoshizawa K, Jokinen MP, Brix AE, Sells DM, Wyde ME, Orzech DP, Kissling GE, Walker NJ. Olfactory epithelial metaplasia and hyperplasia in female Harlan Sprague-Dawley rats following chronic treatment with polychlorinated biphenyls.  Toxicologic Pathology 2005; 33(3):371-377. [Abstract] ( Exit NIEHS
  7. Emmen JMA, Couse JF, Elmore SA, Yates MM, Kissling GE, Korach KS.  In vitro growth and ovulation of follicles from ovaries of estrogen receptor (ER)α and ERβ null mice indicate a role for ERβ in follicular maturation. Endocrinology, 2005; 146(6):2817-2826. [Abstract] ( Exit NIEHS
  8. Chen Y, Kissling GE, Negishi M, Goldstein J.  The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter.  Journal of Pharmacology and Experimental Therapeutics 2005; 314:1125-1133. [Abstract] ( Exit NIEHS
  9. Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L.  Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: Evidence consistent with a glycidamide-mediated effect.  Mutation Research 2005; 578:284-297. [Abstract] ( Exit NIEHS
  10. Yoshizawa K, Kissling GE, Johnson JA, Clayton NP, Flagler ND, Nyska A.  Chemical-induced atrial thrombosis in NTP rodent studies.Toxicologic Pathology 2005; 33:517-532. [Abstract] ( Exit NIEHS
  11. Drake JW, Bebenek A, Kissling GE, Peddada S.  Clusters of mutations from transient hypermutability. Proceedings of the National Academy of Sciences 2005; 102:12849-12854. [Abstract] ( Exit NIEHS
  12. Tam NNC, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman S, Ho SM.  Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants.  The Prostate 2006; 66:57-69. [Abstract] ( Exit NIEHS
  13. Chan SSL, Santos JH, Meyer JN, Mandavilli BS, Cook Jr. DL, McCash CL, Kissling G, van Houten B, Copeland WC, Walker VE, Witt KL, Bishop JB.  Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination.  Environmental and Molecular Mutagenesis 2006; in press. [Abstract] ( Exit NIEHS
  14. Peddada SD and Kissling GE.  Evaluation of a survival-adjusted quantal-response test for analysis of tumor incidence rates in animal carcinogenicity studies.  Environmental Health Perspectives 2006; 114:537-541. [Abstract] ( Exit NIEHS
  15. Dunnick J, Blackshear P, Kissling G, Cunningham M, Parker J, Nyska A. Critical pathways in heart function:  Bis(2-chloroethoxy)methane-induced heart gene change in F344 rats.  Toxicologic Pathology 2006; 34:348-356. [Abstract] ( Exit NIEHS
  16. Kissling GE, Bernheim NJ, Hawkins WE, Wolfe MJ, Jokinen MP, Smith CA, Herbert RA, Boorman GA.  The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity. Toxicological Sciences 2006; 92:143-156. [Abstract] ( Exit NIEHS
  17. Elliott L, Longnecker MP, Kissling GE, London SJ.  Volatile organic compounds and pulmonary function in the third national National Health and Nutrition Examination Survey, 1988-1994.  Environmental Health Perspectives 2006; 114:1210-1214. [Abstract] ( Exit NIEHS
  18. Fortune JM, Welch CM, Kissling GE, Burgers PMJ, Kunkel TA.  RPA and PCNA suppress formation of large deletion errors by yeast DNA polymerase delta.  Nucleic Acids Research 2006; 34: 4335-4341. [Abstract] ( Exit NIEHS
  19. Clayton NP, Yoshizawa K, Kissling G, Burka LT, Chan P-C, Nyska A.  Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract.  Experimental and Toxicologic Pathology 2006; in press. [Abstract] ( Exit NIEHS
  20. Zhong X, Garg P, Stith C, Nick-McElhinny S, Kissling G, Burgers P, Kunkel T. The fidelity of DNA synthesis by yeast DNA polymerase zeta alone and with accessory proteins.  Nucleic Acids Research 2006; 34: 4731-4742. [Abstract] ( Exit NIEHS
  21. Elangbam CS, Wehe JG, Barton JC, Krull DL, Nyska A, Crabbs T, Kissling GE.  Evaluation of glycosaminoglycans content and 5-hydroxytryptamine 2B receptor in the heart valves of Sprague-Dawley rats with spontaneous mitral valvulopathy--a possible exacerbation by dl-amphetamine sulfate in Fischer 344 rats? Experimental and Toxicologic Pathology 2006; 58: 89-99. [Abstract] ( Exit NIEHS
  22. Peddada SD, Dinse GE, Kissling GE.  Use of historical controls in survival-adjusted quantal response tests for comparing incidence rates of rare tumors.  Journal of the American Statistical Association 2006; in press.
  23. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR,, Herbert RA, Boorman GA.  Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC and p53 haploinsufficient mice.  Toxicological Sciences; in press.
  24. Dumsdorf C, Clark AB, Lin Q, Kissling GE, Yuan T, Kunkel TA, McGregor WG, Kucherlapati R.  Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer.  Proceedings of the National Academy of Sciences 2006; in press. [Abstract] ( Exit NIEHS
  25. Moore AB, Flake GP, Swartz CD, Heartwell G, Cousins D, Haseman JK, Kissling GE, Sidawy MK, Dixon D.  Influence of race, age and body mass index on the gross pathology of uterine fibroids. New England Journal of Medicine; in press.
  26. Golumb E, Houminer E, Dunnick J, Kissling G, Borman J, Nyska A, Schwalb H. Occult cardiotoxicity: Subtoxic dosage of bis(2-chloroethoxy)methane impairs cardiac response to simulated ischemic injury.  Toxicologic Pathology; in press.
  27. Witt KL, Cunningham CK, Patterson KB, Kissling GE, Dertinger SD, Livingston E, Bishop JB.  Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV.  Environmental and Molecular Mutagenesis;  in press.
  28. Kissling GE, Dertinger S, Hayashi M, MacGregor JT. Sensitivity of the Erythrocyte Micronucleus Assay: Dependence on number of cells scored and inter-animal variability. Mutation research 2007; 1-2: 235-240. [Abstract] ( Exit NIEHS
  29. Kissling GE, Malarkey DE, Vallant MK, Johnson JD, Hejtmancik MR, Herbert RA, Boorman GA. Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 2006; 2-3: 89-99. [Abstract] ( Exit NIEHS
  30. Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, Herbert R , Diaz M.. Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr Mice. Journal of Immunology (Baltimore, Md. : 1950) 2007; 11: 7422-7431. [Abstract] ( Exit NIEHS
  31. Melnick RL, Nyska A, Foster PM, Roycroft JH, Kissling GE. Toxicity and carcinogenicity of the water disinfection byproduct, dibromoacetic acid, in rats and mice. Toxicology 2007; 2-3: 126-136. [Abstract] ( Exit NIEHS
  32. Bennett WD , Hazucha MJ, Folinsbee LJ, Bromberg PA, Kissling GE, London SJ. Acute pulmonary function response to ozone(O3) in young adults as a function of body mass index (BMI). Inhalation toxicology 2007; 19(14):1147-1154. [Abstract] ( Exit NIEHS
  33. Stout MD, Herbert RA, Kissling GE, Suarez F, Roycroft JH, Chhabra RS, Bucher JR. Toxicity and carcinogenicity of methyl isobutyl ketone in F344N rats and B6C3F1 mice following two year inhalation exposure. Toxicology 2008; 244(2):209-219. [Abstract] ( Exit NIEHS
  34. Thigpen JE, Setchell KDR, Haseman JK, Saunders HE, Caviness GF, Kissling GE, Grant MG, Forsythe DB. Variations in phytoestrogen content between different mill dates of the same diet produces significant differences in the time of vaginal opening in CD-1 mice and F344 rats but not in CD Sprague Dawley rats. Environmental health perspectives 2007; 115(12):1717-1726. [Abstract] ( Exit NIEHS
  35. Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutation research 2008; 649(1-2):101-113. [Abstract] ( Exit NIEHS
  36. Kissling GE, Portier CJ, Huff J. MtBE and cancer in animals: statistical issues with poly-3 survival adjustments for lifetime studies. Regulatory toxicology and pharmacology : RTP 2008; 50(3):428-429. [Abstract] ( Exit NIEHS
  37. Longnecker MP, Smith CS, Kissling GE, Hoppin JA, Butenhoff JL, Decker E, Ehresman DJ, Ellefson ME, Flaherty J, Gardner MS, Langlois E, LeBlanc A, Lindstrom AB, Reagen WK, Strynar MJ, Studabaker WB. An interlaboratory study of perfluorinated alkyl compound levels in human plasma. Environmental Science and Technology 2008; 107(2):152-159. [Abstract] ( Exit NIEHS

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