| Agent Name |
Cyclohexanone |
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| CAS Number |
108-94-1 |
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| Formula |
C6-H10-O |
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| Major Category |
Solvents |
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| Synonyms |
Anon; Anone; Cyclohexanone; Cyclohexyl ketone; Hexanon; Hytrol O; Ketohexamethylene; Nadone; Pimelic ketone; Pimelin ketone; Sextone; [ChemIDplus] UN1915 |
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| Category |
Ketones |
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| Description |
Water-white to pale-yellow liquid with a peppermint- or acetone-like odor; [NIOSH] |
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| Sources/Uses |
Has many uses as an industrial solvent; used as a paint remover and in printing inks; [ACGIH] |
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| Comments |
Liquid causes first degree burns on short exposure; [CHRIS] Animals become stuporous in high-dose inhalation studies and develop liver necrosis after high-dose feeding studies. [ACGIH] [Sanmartin O, et al. Occupational contact dermatitis from cyclohexanone as a PVC adhesive. Contact Dermatitis. 1992 Sep;27(3):189-90. No abstract available. Abstract in NIOSHTIC #179644] |
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| Reference Link |
Contact allergy to a cyclohexanone resin in humans and guinea pigs |
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| Exposure Assessment |
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| BEI |
1,2-Cyclohexanediol (with hydrolysis) in urine: 80 mg/L (end of shift at end of workweek); Cyclohexanol (with hydrolysis) in urine: 8 mg/L (end of shift); See notations in ACGIH TLVs and BEIs. |
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| Skin Designation (ACGIH) |
Yes |
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| TLV (ACGIH) |
20 ppm |
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| PEL (OSHA) |
50 ppm |
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| IDLH (NIOSH) |
700 ppm |
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| Excerpts from Documentation for IDLHs |
It has been reported that exposure to 75 ppm for 3 to 5 minutes has resulted in pronounced irritation of the eyes, nose, and throat [Nelson et al. 1943]. |
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| Vapor Pressure |
5 mm Hg |
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| Odor Threshold Low |
0.12 ppm |
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| Odor Threshold High |
100 ppm |
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| RD50 |
756 ppm |
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| Lethal Concentration |
LC50 (rats) = 8,000 ppm/4 hr |
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| Explanatory Notes |
Detection odor threshold from AIHA (mean = 3.5 ppm); Flash point = 44 deg C; |
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| Half Life |
For 1,2-cyclohexanediol and 1,4-cyclohexanediol: 14-22 hours; [TDR, p. 434] |
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| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
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| Flammability (NFPA) |
2: high ambient temperature required |
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| Adverse Effects |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Neurotoxin |
CNS Solvent Syndrome |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: CYCLOHEXANONE
|
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