Monday, March 15, 2004 |
8:30 - 8:45 a.m. |
Welcome: Elias Zerhouni, Director, National Institutes of Health |
8:45 - 8:50 a.m. |
Greetings from Sponsoring Institutes:
Jeremy Berg, Director, National Institute of General Medical Sciences |
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Moderator: John Schwab
National Institute of General Medical Sciences |
8:50 - 9:15 a.m. |
Christopher Austin, National Human Genome Research Institute
Small Molecules and the NIH Roadmap |
9:15 - 9:55 a.m. |
Daniel Kahne, Princeton University
Glycopeptide Antibiotics and Cell Envelope Biogenesis |
9:55 - 10:35 a.m. |
Stuart Schreiber, Harvard University
Dissecting Disease Biology and Advancing Medicine with Small Molecules |
10:35 - 10:50 a.m. |
Break |
10:50 - 11:30 a.m. |
Craig Crews, Yale University
A Small Molecule Approach to Target Identification and Validation |
11:30 - 12:10 p.m |
Carolyn Bertozzi, University of California, Berkeley
Chemical Approaches to Studying Protein Glycosylation |
12:10 - 1:00 p.m. |
Lunch |
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Moderator: Christopher Austin
National Human Genome Research Institute |
1:00 - 1:40 p.m. |
David Liu, Harvard University
An Evolution-Based Approach to the Creation and Discovery of Functional Synthetic Molecules |
1:40 - 2:20 p.m. |
Roger Tsien, University of California, San Diego
Genetically and Proteolytically Targeted Sequences for Imaging from Ultrastructure to Whole Mammals |
2:20 - 3:00 p.m. |
Jeremy Berg, Director, National Institute of General Medical Sciences
Chemical Approaches to Zinc Finger Protein Analysis and Design |
3:00 - 3:20 p.m. |
Break |
3:20 - 4:00 p.m. |
Jon Ellman, University of California, Berkeley
Combinatorial Chemistry Targeting Protein Families |
4:00 - 4:40 p.m. |
Gary Glick, University of Michigan
Chemistry and Biology of Immunosuppressive Benzodiazepines |
4:40-5:20 p.m. |
Stephen Fesik, Abbott Laboratories
NMR-Based Screening of Fragment Libraries for Drug Discovery
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Tuesday, March 16, 2004 |
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Moderator: John Beutler
National Cancer Institute |
8:30 - 9:15 a.m. |
Kevan Shokat, University of California, San Francisco
Chemical Tools for Deciphering Cell Signaling Pathways |
9:15 - 10:00 a.m. |
David Diller, Pharmacopeia
The Role of Computation When Building
Collections of Millions of Compounds |
10:00 - 10:45 a.m. |
Virginia Cornish, Columbia
Co-opting Nature for Chemical Diversity |
10:45 - 11:15 a.m. |
Break |
11:15 - 12:00 p.m. |
DimitriusAgrafiotis, 3-Dimensional Pharmaceuticals
Molecular Informatics for the New Drug Discovery Enterprise
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12:00 - 1:00 p.m. |
Lunch |
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Moderator: Carole Bewley, National Institute of Diabetes and
Digestive and Kidney Diseases |
1:00 - 1:40 p.m |
Chaitan Khosla, Stanford University
Discovery and Development of New Natural Product Drugs:
The Example of Polyketides |
1:40 - 2:20 p.m. |
Baldomero Olivera,University of Utah Conus Peptides: From Genes to Venoms to Drugs |
2:20 - 3:00 p.m. |
Michael Organ, York University
New Advances in the Screening of Compound Mixtures |
3:00 - 3:20 p.m. |
Break |
3:20 - 4:00 p.m. |
Alan Verkman, University of California, San Francisco
Drug Discovery in Academia: CFTR Chloride Channel Inhibitors and Activators for Cystic Fibrosis |
4:00 - 4:40 p.m. |
Eric Lander, The Broad Institute of MIT and Harvard |
4:40 - 5:00 p.m. |
Closing Remarks:
Alan Guttmacher, Deputy Director, National Institute of General Medical Sciences |