| Agent Name |
Triglycidyl isocyanurate |
|---|
| Alternative Name |
1,3,5-Triglycidyl-s-triazinetrione |
|---|
| CAS Number |
2451-62-9 |
|---|
| Formula |
C12-H15-N3-O6 |
|---|
| Major Category |
Plastics & Rubber |
|---|
| Synonyms |
TGIC; Triglycidyl isocyanurate; Teroxirone; Tris(epoxypropyl)isocyanurate; Tris(2,3-epoxypropyl) isocyanurate; TGT; XB 2615; 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(oxiranylmethyl)-,(alpha)-; 1,3,5-Triglycidylisocyanuric acid; 1,3,5-Tris(oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione; 1,3,5-Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione; Glycidylisocyanurate; N,N`,N``-Triglycidylisocyanurate; Tris(2,3-epoxypropyl)-s-triazine-2,4,6(1H,3H,5H)-trione; Araldite PT-810; Isocyanuric acid triglycidyl ester; [ChemFinder]1,3,5-Triglycidyl-s-triazinetrione; [ACGIH] |
|---|
| Category |
Epoxy Resins |
|---|
| Description |
White crystalline or granular solid; [ACGIH] |
|---|
| Sources/Uses |
Used in powder coatings containing less than 5% TGIC; [ACGIH] Occupational asthma and allergic contact dermatitis reported in workers manufacturing thermosetting paints; [Reference #1] Causes allergic contact dermatitis in screen-printing workers handling UV-cured inks; [Adams, p. 467] |
|---|
| Comments |
A nonsmoking spray painter, after using a polyester powder paint containing 4% TGIC for four years, developed allergic contact dermatitis and work-related asthma. The painter had negative skin tests for common allergens and negative challenge test with lactose powder. A challenge test with 4% TGIC induced a dual response with a late 23% fall in FEV1. [Piirila P, et al. Occupational Asthma Caused by Triglycidyl Isocyanurate (TGIC). Clin Exp Allergy 1997 May;27(5):510-4] TGIC causes male reproductive damage in high-dose animal studies. [ACGIH] A severe eye irritant; May cause skin sensitization after prolonged contact; [ICSC] |
|---|
| Reference Link |
Occupational asthma caused by triglycidyl isocyanurate (TGIC) |
|---|
| Exposure Assessment |
|---|
| Skin Designation (ACGIH) |
No |
|---|
| TLV (ACGIH) |
0.05 mg/m3 |
|---|
| Lethal Concentration |
LC50 (rats) > 650 mg/m3/4h |
|---|
| Reference Link |
International Chemical Safety Cards (WHO/IPCS/ILO) |
|---|
| Adverse Effects |
|---|
| Asthma |
Yes |
|---|
| Skin Sensitizer |
Yes |
|---|
| Reproductive Toxin |
Yes |
|---|
| Links to Other NLM Databases |
|---|
| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TRIGLYCIDYL ISOCYANURATE
|
|---|
|
|
