Laboratory of Clinical Infectious Diseases

Adriana Marques, M.D.

Chief, Clinical Studies Unit

Description of Research Program

The Clinical Studies Unit (CSU) was created in 1997. Its main objective is the development and conduct of clinical research in areas of interest to the Laboratory of Clinical Infectious Diseases and its senior staff. Clinical projects are underway that complement molecular studies.

Major Areas of Research

• Lyme disease
• Herpes simplex virus infections
• Shingles (herpes zoster virus) infections
• Autoimmune lymphoproliferative syndrome (ALPS)
• Chronic active Epstein-Barr virus disease (CAEBV)

Research Group Members

Nuralem Endale; Rachael Fulton, R.N.; Katie Perkins, N.P.; Susan Price, R.N.; Koneti Rao, M.D.; Siu-Ping Turk, R.N.; Sonia Whittaker, L.P.N.

Current Clinical Protocols

STARI

• 06-I-0207: Investigation of Southern Tick-Associated Rash Illness (STARI)

Lyme Disease

• 05-I-0219: Microarray Analysis of Erythema Migrans Lesions
• 02-I-0055: Evaluation, Treatment, and Follow-up of Patients with Lyme Disease
• 96-I-0052: A Comprehensive Clinical, Microbiological, and Immunological Assessment of Patients with Suspected Chronic Lyme Infection and Selected Control Populations

Herpes Zoster

• 99-I-0106: Trial of Varicella Vaccine for the Prevention of Herpes Zoster and Its Complications

Epstein-Barr Virus

• 02-I-0147: Genetic Studies of Chronic Active Epstein-Barr Virus Infection

Herpes Simplex Virus

• 97-I-0166: Polymorphism of the Herpes Simplex Virus Receptor

Autoimmune Lymphoproliferative Syndrome

• 08-I-0053: Pilot (Phase I-II) Study of Valproic Acid (Depakote®) for the Treatment of the Autoimmune Lymphoproliferative Syndrome (ALPS)
• 02-I-0308: A Pilot Study of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) for the Evaluation of the Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-Associated Lymphoma
• 95-I-0066: Genetic Analysis of Immune Disorders
• 93-I-0063: Study of the Immunopathogenesis, Natural History, and Genetics of Autoimmune Lymphoproliferative Syndrome (ALPS) Associated with an Expansion of CD4-8-/TCR alpha/beta+ T Cells and Defective Lymphocyte Apoptosis

Selected Publications

To view a complete listing, visit PubMed.

Marques A. Chronic lyme disease: a review. Infect Dis Clin North Am. 2008 Jun;22(2):341-60.

Rao VK. Inside Blood commentary: Taking ALPS down a Notch Blood. Blood. 2008 Jan 15;111(2):477.

Gelderblom H, Schmidt J, Londoño D, Bai Y, Quandt J, Hornung R, Marques A, Martin R, Cadavid D. Role of interleukin 10 during persistent infection with the relapsing fever Spirochete Borrelia turicatae. Am J Pathol. 2007 Jan;170(1):251-62.

Lünemann JD, Gelderblom H, Sospedra M, Quandt JA, Pinilla C, Marques A, Martin R. Cerebrospinal fluid-infiltrating CD4+ T cells recognize Borrelia burgdorferi lysine-enriched protein domains and central nervous system autoantigens in early lyme encephalitis. Infect Immun. 2007 Jan;75(1):243-51. Epub 2006 Oct 23.

Rao VK, Straus SE. Causes and consequences of the autoimmune lymphoproliferative syndrome. Hematology. 2006 Feb;11(1):15-23.

Philipp MT, Wormser GP, Marques AR, Bittker S, Martin DS, Nowakowski J, Dally LG. A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme Borreliosis. Clin Diagn Lab Immunol. 2005 Sep;12(9):1069-74.

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