Workshop on the Establishment, Maintenance, & Turnover of Fat Depots, May 21-22, 2007
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Workshop on the Establishment, Maintenance, & Turnover of Fat Depots, May 21-22, 2007
DRAFT AGENDA
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Day 1                         Wednesday, May 21, 2008

7:30 a.m.

Registration and Continental Breakfast
(Lister Hill Auditorium, NIH Campus)

8:15–8:30 a.m. Opening Remarks/Meeting Overview
8:30–9:15 a.m. Keynote 1:  
The Developmental Origins of Fat and Its Impact on Disease
C. Ronald Kahn, M.D., Joslin Diabetes Center, Harvard University
9:15–10:00 a.m. Keynote 2:  Are Skeletal Muscle Stem Cells Responsible for Fat Accumulation in Aging Muscle?
Brad Olwin, Ph.D., University of Colorado at Boulder
10:00–10:30 a.m. Break
Session I: Adipose Fate Determination (Precursor/Progenitor Cells)
C. Ronald Kahn (Moderator)
10:30–11:00 a.m. Fat Cell Progenitors:  Origin and Plasticity
Christian Dani, Ph.D., University of Nice 
11:00–11:30 a.m. The Tortuous Path of the Adipogenic Lineage
Jonathan Graff, M.D., Ph.D., University of Texas Southwestern Medical Center
11:30–12:00 p.m. Distinct Origins of Brown and White Adipocytes
Barbara Cannon, Ph.D., The Wenner-Gren Institute/Stockholm University
12:00–12:30 p.m. PRDM16 Controls the Determination of Brown Fat Cells From Myogenic Precursors
Patrick Seale, Ph.D., Dana-Farber Cancer Institute/Harvard Medical School          
12:30–2:30 p.m. Poster Session and Lunch Buffet in Atrium
   
Session II: Development of the Niche (Role of Secreted Signals and the ECM)
Jon Graff (Moderator)
2:30–3:00 p.m.

Role of Wnt Signaling in Development of Adipose Tissues and Bone
Ormond MacDougald, Ph.D., University of Michigan

3:00–3:30 p.m. Adipose Tissue and Adipose Tissue Vasculature Development: Depot Dependent Expression of Genes and Proteins
Gary Hausman, Ph.D., University of Georgia       
3:30–4:00 p.m.

Collagenolytic Remodeling of Fat Tissue Architecture During Obesity Progression
Tae-Hwa Chun, M.D., Ph.D., University of Michigan

4:00–4:30 p.m.  Break
4:30–5:00 p.m. Novel Role of Bone Morphogenetic Protein-7 in Brown Adipogenesis and Energy Expenditure
Yu-Hua Tseng, Ph.D., Joslin Diabetes Center, Harvard University
5:00–5:15 p.m. Hot Topic—Mapping the Adipogenic Lineage of the Human Mesenchymal Stem Cell
Danielle MacKay, Ph.D., Case Western Reserve University
5:15–5:30 p.m. Hot Topic—Myostatin, Activin Receptor IIb and Follistatin-like Gene Expression is Altered in Adipose Tissue of Obese Mice
David Allen, Ph.D., University of Colorado, Boulder
5:30 p.m. Adjourn
 
Day 2                         Thursday, May 22, 2008
7:30–8:00 a.m.

Registration and Continental Breakfast
(Lister Hill Auditorium, NIH Campus)

   
Session III: Cellular Diversity and Turnover in Fat Depots
Jim Granneman (Moderator)           
8:00–8:30 a.m.

Regional Differences in Preadipocytes:  Are Different Fat Depots Distinct Mini-Organs? 
James Kirkland, M.D., Ph.D., Boston University

8:30–9:00 a.m.

A Role of p107 in Mesodermal Cell Fate Decisions
Anthony Scime, Ph.D., University of Ottawa

9:00–9:15 a.m. Hot Topic—Functions of PPARγ in Early Adipogenesis in vivo and in vitro
Suyeon Kim, Ph.D., The Jackson Laboratory
9:15–9:30 a.m. Hot Topic—Atf4 Mutant Mice are Lean
Jin Seo, Ph.D., University of Texas Southwestern Medical Center
9:30–10:00 a.m. Break
10:00–10:30 a.m.

Critical Factors Restricting Fat Expansion
Phillip Scherer, Ph.D., University of Texas Southwestern Medical Center

10:30–11:00 a.m. Dynamics of Adipose Tissue Components in Vivo in Experimental Animals and Humans: Modulation by Genes, Hormones and Drugs
Marc Hellerstien, M.D., Ph.D., University of California at Berkeley
11:00–11:15 a.m. Hot Topic—Dysregulation of Adipocyte Biology and Metabolic Profile by Ablation of α3(V) Collagen
Daniel Greenspan, Ph.D., University of Wisconsin
11:15–11:30 a.m. Hot Topic—Cidea and FSP27: Novel Proteins Associated with Fat Metabolism and Insulin Sensitivity in Humans
Vishwajeet Puri, Ph.D., University Massachusetts Medical School
11:30–11:45 a.m. Hot Topic—Factors Contributing to Metabolically Normal Adiposity
Nikhil Dhurandhar, Ph.D., Pennington, Louisiana State University System
11:45–1:15 p.m. Poster Session and Lunch Buffet
   

Session IV: Remodeling and Plasticity of Fat Depots
Phillip Gorden (Moderator)      

1:15–1:45 p.m.

Cellular and Metabolic Plasticity of White Adipose Tissue: Effects of β-Adrenergic Stimulation
James Granneman, Ph.D., Wayne State University

1:45–2:15 p.m.

Depot Selective Role for Macrophages in Obesity-Associated Adipose Tissue Remodeling
Martin Obin, Ph.D., Tufts University

2:15–2:45 p.m.

Exploring Inflammatory Links Between Obesity and Diabetes
Alan Saltiel, Ph.D., University of Michigan

2:45–3:15 p.m.

Bone Marrow Mesenchymal Progenitor Cells Give Rise to a Unique Adipocyte Population in Adipose Tissue
Dwight Klemm, Ph.D., University of Colorado Health Sciences Center

3:15–3:30 p.m.  Hot Topic—Identification of G0S2 as a Novel Bcl-2 Binding Protein Regulator in Adipocytes
Jun Liu, Ph.D., University of Kentucky, School of Medicine
3:30–3:45 p.m. Hot Topic—Rapid Improvement of Glucose Tolerance Independent of Loss of Weight by a Peptide Inducing Apoptosis in Endothelium of White Adipose Tissue
Dong-Hoon Kim, M.D., University of Cincinnati
3:45–4:00 p.m.  Closing Remarks
4:00 p.m. Adjourn