LocusLink
ID |
Symbol |
Common name |
Position |
Aliases |
Binds
to Receptor(s) |
OMIM ID |
Key Functions |
Phenotype
associated with overexpression |
Phenotype
associated with deficiency |
Human
Genetic Diseases |
4049 |
TNFSF1 |
Lymphotoxin alpha (Lta) |
6p21.3 |
LT,
TNFB, TNFSF1 |
TNFR2 (1B), TNFR1 (1A), HVEM (14) |
153440 |
lymphoid organ formation |
|
Absence of LN and PP, defective GC
formation |
|
7124 |
TNFSF2 |
tumor necrosis factor (TNF) |
6p21.3 |
DIF,
TNFA, TNFSF2, CACHECTIN |
TNFR2 (1B), TNFR1 (1A) |
191160 |
inflammation |
Wasting syndrome, arthritis |
defective GC formation, resistance
to endotoxic shock and experimental arthritis |
TNF2 (G-308A) promotor polymorphism
associated with increased susceptability to septic shock. asthma and RA
severity |
4050 |
TNFSF3 |
lymphotoxin beta (LTb) |
6p21.3 |
p33,
TNFC, TNFSF3 |
as a b2a1 heterotrimer with LT-a binds
to LT-b Receptor (3) |
600978 |
lymphoid organ formation |
Ectopic lymphoid organ formation |
|
|
7292 |
TNFSF4 |
OX40 Ligand |
1q25 |
GP34,
OX4OL, TXGP1, CD134L, OX-40L |
OX40 (4) |
603594 |
CD4 T cell expansion, survival, and
Th2 development |
Increased Th2 responses |
Th2 deficiency, blockade improves
EAE |
|
959 |
TNFSF5 |
CD40 Ligand |
Xq26 |
IGM,
IMD3, TRAP, gp39, CD154, CD40L, HIGM1, T-BAM, |
CD40 (5) |
300386 |
Costimulation and differentiation
of B cells and APC |
Constitutive expression in B cells
or keratinocytes leads to SLE-like
syndrome |
Immunodeficiency due to Defective
Ig class switching and germinal center formation |
X-linked hyper-IGM syndrome
associated with CD40L loss of function mutations |
356 |
TNFSF6 |
Fas Ligand |
1q23 |
FASL,
CD178, CD95L, APT1LG1 |
Fas (6), DcR3 (6B) |
134638 |
Mediator of CD4(+) T cell apoptosis
due to restimulation and apoptosis in other cell types |
|
Lymphadenopathy and Systemic
Autoimmunity |
Autoimmune Lymphoproliferative
Syndrome (ALPS) type Ib |
970 |
TNFSF7 |
CD27 Ligand |
19p13 |
CD70,
CD27L, CD27LG |
CD27 (7) |
602840 |
T cell costimulation |
T cell hyperactivation eventually
leading to immunodeficiency
(HIV-like) |
|
|
944 |
TNFSF8 |
CD30 Ligand |
9q33 |
CD153,
CD30L, CD30LG |
CD30 (8) |
603875 |
|
|
|
|
8744 |
TNFSF9 |
4-1-BB Ligand |
19p13.3 |
4-1BB-L |
4-1BB (9) |
606182 |
T cell costimulation |
|
|
|
8743 |
TNFSF10 |
(TNF-like apoptosis inducing ligand)TRAIL |
3q26 |
TL2,
APO2L, TRAIL, Apo-2L |
DR4 (10A), DR5 (10B), DcR1 (10C),
DcR2 (10D) |
603598 |
Dendritic cell apoptosis, NK-cell
mediated tumor cell killing |
|
defective NK-mediated tumor
eradication |
|
8600 |
TNFSF11 |
RANK-L |
13q14 |
ODF,
OPGL, sOdf, RANKL, TRANCE, hRANKL2 |
RANK (11A) |
602642 |
mediates osteoclast formation and
bone remodeling. Stimulation of APC |
|
|
|
8742 |
TNFSF12 |
TWEAK |
17p13 |
APO3L,
DR3LG, TWEAK, MGC20669 |
TWEAK-R (12A) |
602695 |
Potential
role in inflammation and lymphocyte function |
|
|
|
8741 |
TNFSF13 |
APRIL |
17p13.1 |
APRIL,
TALL2, TWE-PRIL |
TACI (13B), BCMA (17) |
604472 |
Promotes T-independent type-2
responses through interactions with TACI |
overexpression in T cells produces
prolonged T cell survival and enhanced TI-2 responses |
|
|
10673 |
TNFSF13B |
BlyS, BAFF |
13q32-34 |
BAFF,
BLYS, TALL1, THANK, ZTNF4 |
TACI (3B), BAFF-R (13C), BCMA(17), |
603969 |
promotes B cell maturation,
plasmablast survival |
SLE-like systemic autoimmunity and
arthritis |
|
|
8740 |
TNFSF14 |
LIGHT |
19p13.3 |
LTg,
TR2, HVEML, LIGHT |
HVEM (14), LT-bR (3),
DcR3 (6B) |
604520 |
CD8 T cell and APC costimulation, |
inflammation, T cell
hyperactivation Th1 bias |
defective CD8 T cell costimulation |
|
9966 |
TNFSF15 |
TL1A |
9q32 |
TL1,
TL1A, VEGI |
DR3 (25) |
604052 |
Recently identified ligand for DR3
(TNFRSF25) |
|
Blockade impairs T Cell-mediated immunopathology |
|
8995 |
TNFSF18 |
GITR Ligand |
1q23 |
TL6,
AITRL, GITRL, hGITRL |
GITR (18) |
603898 |
T cell costimulation (+)CD25(+) regulatory
T cells |
|
|
|
1896 |
ED1 |
ectodermal dysplasia 1, anhidrotic (EDA1) |
X |
EDA,
HED, EDA1, XHED, XLHED |
EDAR |
305100 |
Tooth, hair and Sweat gland
formation |
|
|
X-LINKED ECTODERMAL DYSPLASIA |
LocusLink
ID |
Symbol |
Common Name(s) |
Position |
Aliases |
Binds to Ligand(s) |
OMIMID |
Key Functions |
Phenotype associated with
deficiency |
Human
Genetic Diseases |
7132 |
TNFRSF1A |
tumor
necrosis factor receptor 1 (TNF-R1) |
12p13.2 |
FPF, p55, p60, TBP1, TNF-R, TNFAR,
TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55, MGC19588 |
TNFa (2), Lta (1) |
191190 |
Mediates TNF-induced inflammation
(and apoptosis in some cells) |
resistance to TNF-induced
artrhritis models, resistant to endotoxic shock, Increased sensitivity to
bacterial pathogens |
Periodic
fever syndrome(TRAPS)associated with heterozygous extracellular mutaions |
7133 |
TNFRSF1B |
tumor necrosis factor receptor 2
(TNF-R2) |
1p36.3-p36.2 |
p75, TBPII, TNFBR, TNFR2, CD120b,
TNFR80, TNF-R75, p75TNFR, TNF-R-II |
TNFa (2), Lta (1) |
191191 |
May enhance pro-apoptotic effect of
TNFR1 |
still susceptible to TNF-induced
arthritis models, defective CD8(+) T cell apoptosis after restimulation, Increased sensitivity to bacterial
pathogens |
|
4055 |
TNFRSF3 |
lymphotoxin beta receptor |
12p13 |
LTBR, CD18, TNFCR, TNFR-RP,
TNFRSF3, TNFR2-RP, LT-BETA-R, TNF-R-III |
LIGHT (14), LTb (3) |
600979 |
lymphoid organ formation |
No LN, PP, defective GC formation |
|
7293 |
TNFRSF4 |
OX40 |
1p36 |
OX40, ACT35, CD134, TXGP1L |
OX40L (4) |
600315 |
T cell costimulation |
Defective CD4 T cell responses |
|
958 |
TNFRSF5 |
CD40 |
20q12-q13.2 |
p50, Bp50, CD40, CDW40, MGC9013 |
CD40L (5) |
109535 |
Costimulation and differentiation
of B cells and APC |
Defective Ig class switching and
germinal center formation |
Autosomal
hyper-IgM syndrome associated with loss-of function mutations |
355 |
TNFRSF6 |
Fas,
CD95 |
10q24.1 |
FAS, APT1, CD95, APO-1 |
FasL (6) |
134637 |
Apoptosis of restimulated CD4 T
cells, B cells, ?others |
Defective apoptosis of restimulated
CD4(+) T cells |
Autoimmune
Lymphoproliferative Syndrome (ALPS) associated with heterozygous
dominat-interfering mutations |
8771 |
TNFRSF6B |
Decoy Receptor 3 |
20q13.3 |
M68, TR6, DCR3, DJ583P15.1.1 |
FasL (6), TL1A (15), LIGHT (14) |
603361 |
Soluble decoy receptor for FasL,
LIGHT, and TL1A. May have a role in tumor immune evasion |
|
|
939 |
TNFRSF7 |
CD27 |
12p13 |
T14, CD27, S152, Tp55, MGC20393 |
CD27L (7) |
186711 |
T cell costimulation |
Defective T cell responses |
|
943 |
TNFRSF8 |
CD30 |
1p36 |
CD30, KI-1, D1S166E |
CD30L (8) |
153243 |
? Inhibition of CD8 T cell effector function |
|
|
3604 |
TNFRSF9 |
4-1BB, CD137 |
1p36 |
ILA, 4-1BB, CD137, CDw137, MGC2172 |
4-1BBL (9) |
602250 |
T cell costimulation |
Defective CD8 T cell responses |
|
8797 |
TNFRSF10A |
Death
Receptor 4 (DR4) |
8p21 |
DR4, APO2, MGC9365, TRAILR1,
TRAILR-1 |
TRAIL (10) |
603611 |
Mediator of dendritic cell and
tumor cell apoptosis |
|
|
8795 |
TNFRFRSF10B |
Death
Receptor 5 (DR5) |
8p22-p21 |
DR5, KILLER, TRICK2, TRICKB,
ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5 |
TRAIL (10) |
603612 |
Mediator of dendritic cell and
tumor cell apoptosis |
|
|
8794 |
TNFRSF10C |
Decoy Receptor 1 |
8p22-p21 |
LIT, DCR1, TRID, TRAILR3 |
TRAIL (10) |
603613 |
GPI-linked Decoy receptor,
interferes with TRAIL function |
|
|
8793 |
TNFRSF10D |
Decoy Receptor 2 |
8p21 |
DCR2, TRUNDD, TRAILR4 |
TRAIL (10) |
603614 |
Transmembrane decoy receptor,
interferes with TRAIL function |
|
|
8792 |
TNFRSF11A |
(Receptor activator of NF-kappa B)
RANK |
18q22.1 |
OFE, ODFR, PDB2, RANK, TRANCER |
RANKL (11) |
603499 |
mediates DC costimulation and
osteoclast maturation and activation |
Osteopetrosis due to osteoclast
deficiency, no lymph nodes, impaired B cell development |
|
4982 |
TNFRSF11B |
Osteoprotegerin (OPG) |
8q24 |
OPG, TR1, OCIF, MGC29565 |
TRAIL (10), RANKL (11) |
602643 |
Soluble decoy receptor for RANK |
osteoporosis, arterial
calcification |
|
51330 |
TNFRSF12A |
TWEAK-receptor |
16p13.3 |
FN14, TWEAKR |
TWEAK (12) |
605914 |
|
|
|
8791 |
TNFRSF12L |
tumor necrosis factor receptor
superfamily, member 12-like |
1p36.2 |
DR3-Like |
|
|
|
T cell hyperactivation, increased
susceptibility to restimulation-induced apoptosis |
|
LocusLink
ID |
Symbol |
Common Name(s) |
Position |
Aliases |
Binds to Ligand(s) |
OMIMID |
Key Functions |
Phenotype associated with
deficiency |
Human Genetic Diseases |
23495 |
TNFRSF13B |
TACI |
17p11.2 |
TACI |
APRIL (13), BAFF (13B) |
604907 |
May inhibit some of the
pro-survival effects of BAFF-R |
Decreased TI-2 B cell responses,
but B cell hyperplasia and autoimmunity |
|
115650 |
TNFRSF13C |
BAFF receptor (BAFF-R) |
22q13.1-q13.31 |
BAFF/BLyS receptor 3 |
BAFF (13B) |
606269 |
|
Impaired survival of immature
transitional B cells |
|
8764 |
TNFRSF14 |
Herpes Virus Entry Mediator (HVEM) |
1p36.3-p36.2 |
TR2, ATAR, HVEA, HVEM, LIGHTR |
LIGHT (14), Herpesviruses |
602746 |
|
|
|
4804 |
TNFRSF16 |
NGF-R |
17q21-q22 |
TNFRSF16, p75(NTR) |
NGF (not a TNF family member) |
162010 |
NGF receptor - evolutionary outlier
as NGF not classical TNF family molecule |
Defective sensory
neuron innervation; impaired heat sensitivity |
|
608 |
TNFRSF17 |
B cell maturation antigen (BCMA) |
16p13.1 |
BCM |
APRIL (13), BAFF (13B) |
109545 |
|
apparently no B cell phenotype |
|
8784 |
TNFRSF18 |
Glucocorticoid-induced TNF receptor
(GITR) |
1p36.3 |
AITR, GITR, GITR-D |
GITRL (18) |
603905 |
T cell costimulation, marker for
CD4(+)CD25(+) Treg cells, modulates Treg function |
T cell hyperactivation |
|
55504 |
TNFRSF19 |
Toxicity and JNK inducer (TAJ) |
13q12.11-q12.3 |
TROY, TRADE, TAJ-alpha |
|
606122 |
similar to EDAR, expressed in skin
and brain |
|
|
84957 |
TNFRSF19L |
RELT |
11q13.3 |
RELT, FLJ14993 |
|
|
possible T cell costimulator |
|
|
27242 |
TNFRSF21
|
Death
Receptor 6 (DR6) |
6p21.1-12.2 |
DR6, BM-018 |
|
605732 |
negative regulator B and T cell
responses |
enhanced T and B cell activation |
|
94098 |
TNFRSF22 |
tumor necrosis factor receptor
superfamily, member 22 |
11p15.5 |
SOBa, Tnfrh2, 2810028K06Rik |
|
|
|
|
|
94099 |
TNFRSF23 |
tumor necrosis factor receptor
superfamily, member 23 |
11p15.5 |
mSOB, Tnfrh1 |
|
|
|
|
|
8718 |
TNFRSF25 |
Death
Receptor 3 (DR3) |
1p36.2 |
DR3,
TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12 |
TL1A
(15) |
603366 |
|
?impaired
thymic negative selection |
|
10913 |
EDAR |
ectodysplasin
1, anhidrotic receptor |
2q11-q13 |
DL, ED3, ED5, ED1R, EDA3, EDA-A1R |
E1 |
604095 |
tooth, hair, sweat gland formation |
abnormal tooth, hair,
and sweat gland formation |
Ectodermal Dysplasia |
60401 |
XEDAR |
XEDAR: ectodysplasin A2 isoform
receptor |
Xq12 |
EDAA2R, EDA-A2R |
EDA-A2 |
300276 |
|
|
|
KEY
Locuslink
ID: Gene “homepage” curated by NCBI. Go To http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene
and type the locuslink ID in the search window
OMIM: ID
in the Online Mendelian Inheritance in Man Database. Go to http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
and type in the OMIM ID in the search window
Abbreviations:
LN: Lymph Node, PP: Peyer’s Patch, GC: Germinal Center