Cancer Control Research
1R01CA076333-01
Gilchrest, Barbara A.
MELANOMA CONTROL FOR SIBLING OF MELANOMA PATIENTS
AbstractDESCRIPTION: With low cost screening and preventive procedures readily
available, no one should die of cutaneous melanoma. Promoting melanoma
control for at risk populations through regular skin cancer screening and
sun protection practices should counter this modern cancer epidemic.
Siblings (and other first-degree relatives) of melanoma patients have a two
- eight fold elevated relative risk of developing melanoma themselves but
have suboptimal knowledge of their risk and limited practice of screening
and prevention measures. To date, no intervention protocols have targeted
this high risk sibling group, a population estimated to be up to
three-quarters million or more Americans.
The investigators propose a randomized trial testing personalized telephone
counseling intervention support and screening (PERTCISS) that delivers
melanoma risk information to siblings and promotes screening and prevention
practices. They propose to intervene at a time of a new diagnosis of
melanoma in a family member, capitalizing on this teachable moment to reach
siblings. They will randomize 450 adult siblings (New England residents) of
newly diagnosed melanoma patients to PERTCISS or standard care (SC).
The specific aims are to determine, in siblings, the impact of PERTCISS
compared to SC on melanoma screening and prevention practices, as well as
the knowledge and attitudes that mediate and motivate these practices. They
hypothesize that, compared to those in SC, siblings randomized to PERTCISS
will demonstrate: 1) Higher levels of three practices: a) physician skin
cancer screening examinations, b) skin self-examination for melanoma, c) sun
protection practices; and 2) Higher levels of knowledge about melanoma risk
and improved attitudes about early detection and prevention.
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