| Agent Name |
Tetrakis(hydroxymethyl)phosphonium sulfate |
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| CAS Number |
55566-30-8 |
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| Formula |
C8-H24-O8-P2.O4-S |
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| Major Category |
Other Classes |
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| Synonyms |
Bis(tetrakis(hydroxymethyl)phosphonium)sulfate (salt); Octakis(hydroxymethyl)phosphonium sulfate; Phosphonium, tetrakis(hydroxymethyl)-, sulfate (2:1) (salt); Pyroset TKO; THPS; Retardol S; [ChemIDplus] |
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| Category |
Phosphorus Compounds |
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| Description |
Crystalline solid; [ACGIH] Available commercially as an aqueous solution; [MSDSonline] |
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| Sources/Uses |
Used to make crease-resistant and flame-retardant finishes for textiles, e.g., children's sleepwear; [ACGIH] Also used as a biocide; [HSDB] |
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| Comments |
May cause sensitization by skin contact or inhalation; [CHEMINFO] Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) was a sensitizer in 14 of 20 guinea pigs; Tetrakis (hydroxymethyl) phosphonium chloride (THPC) was not a skin sensitizer in tests on human skin; Neither THPS or THPC inhibited acetylcholinesterase; Rats and mice given repeated high oral doses have liver damage; Degrades rapidly in the environment in the presence of moisture and sunlight into trihydroxymethyl phosphine oxide and bis-hydroxymethyl phosphonic acid; [ACGIH] Harmful if swallowed; Corrosive; Causes burns; May cause skin sensitization; Inhalation of high concentrations may cause pneumonitis and pulmonary edema; [MSDSonline] See "Tetrakis(hydroxymethyl)phosphonium chloride." |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
2 mg/m3 |
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| Lethal Concentration |
LC50 (Rat) = 5.5 mg/l/4 hr |
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| Explanatory Notes |
VP = 32 mm Hg @ 124 deg F; [CAMEO] Tetrakis(hydroxymethyl)phosphonium sulfate and Tetrakis(hydroxymethyl)phosphonium chloride are addressed by ACGIH in a single profile for Tetrakis(hydroxymethyl)phosphonium salts. See ACGIH Documentation of TLVs. |
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| Adverse Effects |
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| Toxic Pneumonitis |
Yes |
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| Dermatotoxin |
Skin Burns |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM SULFATE
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