Selected Publications

Environmental Stress & Cancer Group

1. Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP. 2008. DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 456 (7223):819-823. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18849970)
2. Lobenhofer EK, Auman JT, Blackshear PE, Boorman GA, Bushel PR, Cunningham ML, Fostel JM, Gerrish K, Heinloth AN, Irwin RD, Malarkey DE, Merrick BA, Sieber SO, Tucker CJ, Ward SM, Wilson RE, Hurban P, Tennant RW, Paules RS. 2008. Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype. Genome Biology 9 (6):R100. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18570634)
3. Arlander SJH, Greene BT, Innes CL, Paules RS. 2008. DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells. Cancer Research 68 (1):89-97. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=18172300)
4. Bushel PR, Heinloth AN, Li J, Huang L, Chou JW, Boorman GA, Malarkey DE, Houle CD, Ward SM, Wilson RE, Fannin RD, Russo MW, Watkins PB, Tennant RW, Paules RS. 2007. Blood gene expression signatures predict exposure levels. Proceedings of the National Academy of Sciences of the United States of America 104(46):18211-18216. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17984051)
5. Chou JW, Zhou T, Kaufmann WK, Paules RS, Bushel PR. 2007. Extracting gene expression patterns and identifying co-expressed genes from microarray data. BMC bioinformatics 8(1):427-427. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17980031)
6. Auman J.T., G.A. Boorman, R.E. Wilson, G.S. Travlos, and R.S. Paules. 2007. Heat map visualization of high-density clinical chemistry data. Physiological Genomics, 2 352-356. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17652165)
7. Innes, C.L., A.N. Heinloth, K.G. Flores, S.O. Sieber, P.B. Deming, P.R. Bushel, W.K Kaufmann, and R.S. Paules. 2006. ATM requirement in gene expression responses to ionizing radiation in human lymphoblasts and fibroblasts. Mol. Cancer Res., 4, 197-207. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16547157)
8. Members of the Toxicogenomics Research Consortium. 2005. Standardizing global gene expression analysis between laboratories and across platforms. Nat. Methods, 2, 351-356. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15846362)
9. Fannin, R.D., J.T. Auman, M.E. Bruno, S.O. Sieber, S.M. Ward, C.J. Tucker, B.A. Merrick, and R.S. Paules. 2005. Differential gene expression profiling in whole blood during acute systemic inflammation in lipopolysaccharide-treated rats. Physiol. Genomics, 21, 92-104.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15781589)
10. Heinloth, A.N., R.D. Irwin, G.A. Boorman, P. Nettesheim, R.D. Fannin, S.O. Sieber, M.L. Snell, C. J. Tucker, L. Li, G.S. Travlos, G. Vansant, P.E. Blackshear, R.W. Tennant, M.L. Cunningham, and R.S. Paules. 2004. Gene expression profiling of rat livers reveals indicators of potential adverse effects. Toxicol. Sci., 80, 193-202. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15084756)
11. Heinloth, A.N., R.E. Shackelford, C.L. Innes, L. Bennett, L. Li, R.P. Amin, S.O. Sieber, K.G. Flores, P.R. Bushel, and R.S. Paules. 2003. Identification of distinct and common gene expression changes after oxidative stress and gamma and ultraviolet radiation. Mol. Carcinog., 37, 65-82. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12766906)
12. Heinloth, A.N., R.E. Shackelford, C.L. Innes, R.P. Amin, S.O. Sieber, K.G. Flores, L. Bennett, P.R. Bushel, and R.S. Paules. 2003. ATM-dependent and ATM-independent gene expression changes in response to oxidative stress, γ-radiation and UV-radiation. Rad. Res., 160, 273-290. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12926986)
13. Harding, H.P, Y. Zhang, H. Zeng, I. Novoa, P.D. Lu, B. Popko, R.S. Paules, T. Hettmann, J.M. Leiden, and D. Ron. 2003. An integrated stress response promotes resistance to oxidative stress through amino acid sufficiency. Mol. Cell, 11, 619-633. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12667446)
14. Heffernan, T.P., D.A. Simpson, A.R. Frank, A.N. Heinloth, R.S. Paules, M. Cordeiro-Stone, and W.K. Kaufmann. 2002. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell. Biol., 22, 8552-8561. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12446774)
15. Flores, K.G., P.B. Deming, C.S. Downes, R.S. Paules, and W.K. Kaufmann. 2002. ATR enforces the topoisomerase II-dependent G2 checkpoint through Plk1 kinase. J. Biol. Chem., 277, 36832-36838.
16. Hamadeh, H.K., P.R. Bushel, S. Jayadev, K. Martin, O. DiSorba, S. Sieber, L. Bennett, R. Tennant, R. Stoll, J.C. Barrett, K. Blanchard, R.S. Paules, and C.A. Afshari. 2002. Gene expression analysis reveals chemical-specific profiles. Toxicol. Sci., 67, 219-231.  [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12011481)
17. Wolfinger, R.D., G. Gibson, E.D. Wolfinger, L. Bennett, H. Hamadeh, P. Bushel, C.A. Afshari, and R.S. Paules. 2001. Assessing gene significance from cDNA microarray expression data via mixed models. J. Comp. Biol., 8, 625-637. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11747616)
18. Shackelford, R.E, C.L. Innes, S.O. Sieber, A.N. Heinloth, S.A. Leadon, and R.S. Paules. 2001. The ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem., 276, 21951-21959. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11290740)
19. Shackelford, R.E., W.K. Kaufmann, and R.S. Paules. 2000. Oxidative stress and cell cycle checkpoint function. Free Radic. Biol. Med., 28, 1387-1404. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10924858)
20. Kaufmann, W.K. and R.S. Paules. 1996. DNA damage and cell cycle checkpoints. The FASEB J., 10, 238-247. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8641557)
21. Paules, R.S., E.N. Levedakou, S.J. Wilson, C.L. Innes, N. Rhodes, T.D. Tlsty, D.A. Galloway, L.A. Donehower, M.A. Tainsky, and W.K. Kaufmann. 1995. Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res., 55, 1763-1773. [Abstract] (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7712486)

 Back to top