[GCMB Membership Roster] [GCMB Meeting Rosters]

The Gastrointestinal Cell and Molecular Biology [GCMB] Study Section reviews applications pertaining to cell and molecular biology of gastrointestinal and liver function under physiologic and pathophysiologic states.  Studies using cellular, molecular, genetic, structural, biochemical, electrophysiological and pharmacological approaches to define mechanisms and pathways of gastrointestinal (GI) and liver growth, differentiation, development, in humans or model organisms are considered.

Specific areas covered by GCMB:

• Regulation of mechanisms of gene expression at the transcriptional and posttranscriptional levels.
• Mechanisms of development and growth/differentiation control of all cell types in the GI tract and liver. Stem cell biology.
• Molecular physiology of ion channels, pumps and transporters. Molecular mechanisms of GI and liver secretion or absorption. Intracellular signaling pathways in response to endogenous and exogenous stimuli, and intracellular trafficking. Mechanisms of apoptosis, oxidative stress and aging. Epithelial cell biology and barrier function, extracellular matrix- and cell-cell interactions, epithelial repair, regeneration and adaptation.
• Genetic basis of GI diseases, structure/function analysis of disease-causing genes, genotype-phenotype correlation, gene and somatic cell therapy.
• GI and liver dysplasia and pre-neoplasia, mechanisms of transformation; immortalization and mutagenesis.

Study sections with most closely related areas of similar science listed in rank order are:

Hepatobiliary Pathophysiology [HBPP]
Clinical and Integrative Gastrointestinal Pathobiology [CIGP]
Gastrointestinal Mucosal Pathobiology [GMPB]
Cancer Molecular Pathobiology Study Section [CAMP]
Cancer Etiology Study Section [CE]