Our Science – Wang Website

Yun-Xing Wang, Ph.D.

Structural Biophysics Laboratory Head, Protein-Nucleic Acid Interactions Section Investigator Building 538, Room 120 NCI-Frederick Frederick, MD 27102-1201 Phone:   301-846-5985 Fax:   301-846-6231 E-Mail:   wangyu@ncifcrf.gov

Biography

Dr. Wang conducted his graduate work on structure determination of fragments of 23S rRNA using NMR spectroscopy and UV-melting experiments in Professor David E. Draper's lab of the Johns Hopkins University. He received his Ph.D. in October 1994. From 1994 to 2000 he was a postdoctoral later a research fellow in Dr. Dennis Torchia's laboratory where he studied the structure, hydration dynamics of HIV-1 protease in complex with inhibitors and elucidated the 3D structure and a new function of the antitumor/anti-HIV protein MAP30. In the late 2000 he then joined the Structural Biophysics Laboratory of NCI. Using high field NMR spectroscopy and other biophysical and biochemical methods, his group studies the functional structural biology of proteins and RNAs.

Research

The long term research interests of Dr. Wang's lab are using structural biology to understand translational and post-translational processes that are significant to our understanding of cancer biology. With our expertise in structural biology in both protein and RNA, we are currently focused on (1) the post-translational events involving chaperones and receptors in the Wnt/beta-catenin signaling pathway; (2) the structures of 3' untranslated regions (3' UTR) of mRNAs.

This page was last updated on 6/12/2008.