This program supports basic and clinical studies on the pathogenesis, prevention, and treatment of acute kidney injury. Interests include (1) standardized definitions; (2) natural history including risk and outcome stratification for both early disease and progression to chronic renal disease; (3) causes, pathogenetic mechanisms, and pathophysiology in humans and animal models; (4) functional, structural, and imaging markers and strategies for diagnosis, early detection, severity, prognosis, and outcomes; (5) underlying mechanisms leading to prevention, treatment, or enhanced recovery of AKI, and progression to chronic renal disease, including use of pharmaceutical agents, stem cells, and imaging techniques; (6) identification and testing of possible preventive, pre-emptive, or therapeutic interventions that prevent the development, halt progression, or speed recovery of AKI; (7) studies of renal support or replacement strategies to determine the physiological changes or optimal timing, modality, or dose; and (8) economic analyses of the impact of disease and its treatment.
For more information on basic studies, contact Dr. Deborah Hoshizaki, KUH, Director, Kidney and Lower Urinary Tract Development and Repair Program.
For further information on translational or clinical studies, contact Dr. Paul Kimmel, Director, Acute Kidney Injury Clinical Program.
