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Daniel S. Pine, M.D.
This section examines the
relationships among brain development, emotion regulation, and risk for mood and
anxiety disorders in children and adolescents. The broad goal of the section is
to define the manner in which developmental changes in brain function relate to
normal changes in emotion regulation during development and to mood or anxiety
disorders manifest in children and adolescents. To accomplish this goal, the
section emphasizes application of fMRI to questions on emotional development,
performing fMRI studies using various traditional paradigms from cognitive and
affective neuroscience. However, fMRI provides only one tool used to define the
manner in which changes in brain systems relate to development and to manifestations
of mood and anxiety disorders across the lifespan. Other projects will use behavioral
measures of emotion regulation, genetically informative research designs, and treatment
strategies. Overall, the planned studies will answer questions in children and
adolescents on neural correlates of developmental changes in emotional
regulation, risk or symptom patterns in mood and anxiety disorders, as well as
the effects of treatments for mood and anxiety disorders on the Developing brain.
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