Takatoshi, K., Ton, T.T, Lahousse, S.A., Hong, H.L., Wakamatsu, N., Sills, R.C.: K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3’-azido-3’-deoxythymidine. Environ. Mol. Mutagenesis. In Press, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18800350?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Wei B.H., Edwards, J.B., Hoover, S.B., Sheppard H.W., Reed, L.T., Sills, R.C., Simpson, R.M.: Altered beta-catenin accumulation in hepatocelular carcinomas of diethynitrosamine-exposed rhesus macaques. Toxicologic Pathology. In Press, 2008.
Wakamatsu, N., Collins, J.B., Parker, J.S., Tessema, M., Clayton, N.P., Ton, T.V., Hong, H.H., Belinsky, S., Devereux, T.R., Sills ,R.C., Lahoousse, S.A.: Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors. Toxicologic Pathology, 36: 743, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18648096?dopt=Abstract)
Hong H.H., Ton T.T., Kim Y., Wakamatsu N., Clayton N.P., Chan P.C., Sills R.C., Lahousse S.A.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene. Tox. Path. 36: 720, 2008. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18648094?dopt=Abstract)
Wakamatsu, N., Hong, H.L., Devereux, T.R., Sills, R.C.: Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. Tox. Path. 35: 75, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17325975?dopt=Abstract)
Hong, H.L., Houle, C.D., Ton, T.T., Sills, R.C.: K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. Tox. Path. 35: 81, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17325976?dopt=Abstract)
Hong, H.H., Dunnick, J., Herbert, R., Devereux, T.R., Kim, Y., Sills, R.C.: Genetic alterations in K-ras and p53 cancer genes in lung neoplasms of Swiss (CD-1) male mice exposed transplacentally to AZT. Environmental and Molecular Mutagenesis. 48: 299, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16395694?dopt=Abstract)
Houle, C.D., Ton, T., Clayton, N., Huff, J., Hong, H.L., Sills, R.C.: Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary carcinomas from B6C3F1 mice. Tox. Path. 34: 752, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17162533?dopt=Abstract)
Ton, T., Hong, H.H., Devereux, T.R., Melnick, R.L., Sills, R.C., Kim Y.: Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. Chem Biol Interactions. 166: 112, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16860786?dopt=Abstract)
Kim, Y., Ton, T.V., DeAngello, T., Morgan, K., Devereux, T.R., Anna, C., Collins, J.B., Paules, R.S., Crosby, L.M., Sills, R.C.: Major carcinogenic pathways and genes identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats. Toxicol Appl Pharmacol. 214: 144, 2006. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/16460773?dopt=Abstract)
Lambertini, L., Surin, K., Ton, T.V., Clayton, N., Dunnick, J.K., Kim, Y., Hong, H.H., Devereux, T.R., Sills, R.C.: Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy). Tox. Path. 33: 292, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15902973?dopt=Abstract)
Kim, Y., Hong, H.H., Lachat, Y., Clayton, N.P., Devereux, T.R., Melnick, R.L., Hegi, M.E., Sills, R.C.: Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice. Tox. Path. 33: 307, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15814359?dopt=Abstract)
Iida, M., Anna, C.H., Holliday, W.M., Collins, J.B., Cunningham, M.L., Sills, R.C., Devereux, T.R.: Unique patterns of gene expression changes in liver after treatment of mice for 2 weeks with different known carcinogens and non-carcinogens. Carcinogenesis. 26: 689, 2005. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/15618236?dopt=Abstract)
Sills, R.C., Hong, H.L., Flake, G., Moomaw, C., Clayton, N., Boorman, G.A., Dunnick, J., Devereux, T.R.: O-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis. Carcinogenesis, 25: 605, 2004. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/14688030?dopt=Abstract)
Neuropathology Research in Animal Models
Bolon, B., Anthony D.C., Butt, M., Dorman, D., Green, M.V., Little, P., Valentine, W.M., Weinstock, D., Yan, J., Sills, R.C.:“Current Pathology Techniques” symposium review: advances and issues in neuropathology. Toxicologic Pathology. In Press, 2008.
[Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/18812578?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)
Moser, V., Phillips, P.M., McDaniel, K.L., Sills, R.C.: Neurotoxicological evaluation of two disinfection by-products, bromodichloromethane and dibromoacetonitrile in rats. Toxicology. 230: 137, 2007. [Abstract] (http://www.ncbi.nlm.nih.gov/pubmed/17157428?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)