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Our Science – Phang Website

James M. Phang, M.D.

Selected Publications
1)  Surazynski A, Miltyk W, Palka J, Phang JM.
Prolidase-dependent regulation of collagen biosynthesis.
Amino Acids. 2008. [Journal]
2)  Phang JM, Donald SP, Pandhare J, Liu Y.
The metabolism of proline, a stress substrate, modulates carcinogenic pathways.
Amino Acids. 2008. [Journal]
3)  Cooper SK, Pandhare J, Donald SP, Phang JM.
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
J. Biol. Chem. 283: 10485-92, 2008. [Journal]
4)  Phang JM, Pandhare J, Liu Y.
The metabolism of proline as microenvironmental stress substrate.
J. Nutr. 138: 2008S-15S, 2008. [Journal]
5)  Phang JM.
Introduction to second proline symposium.
Amino Acids. 2008. [Journal]
6)  Liu Y, Borchert GL, Surazynski A, Phang JM.
Proline oxidase, a p53-induced gene, targets COX-2/PGE(2) signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.
Oncogene. 2008. [Journal]
7)  Phang JM, Pandhare J, Zabirnyk O, Liu Y.
PPARgamma and Proline Oxidase in Cancer.
PPAR research. 2008: 542694, 2008. [Journal]
8)  Hu CA, Phang JM, Valle D.
Proline metabolism in health and disease.
Amino Acids. 2008. [Journal]
9)  Surazynski A, Donald SP, Cooper SK, Whiteside MA, Salnikow K, Liu Y, Phang JM.
Extracellular matrix and HIF-1 signaling: the role of prolidase.
Int. J. Cancer. 122: 1435-40, 2008. [Journal]
10)  Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM.
Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.
Mol. Cell. Biochem. 295: 85-92, 2007. [Journal]
11)  Liu Y, Borchert GL, Surazynski A, Hu C, Phang JM.
Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
Oncogene, EPub April 17. 25: 5640-5647, 2006. [Journal]
12)  Pandhare J, Cooper SK, Phang JM.
Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms.
J Biol Chem. 281: 2044-52, 2006. [Journal]
13)  Surazynski A, Liu Y, Miltyk W, Phang JM.
Nitric oxide regulates prolidase activity by serine/threonine phosphorylation.
J Cell Biochem. 96: 1086-1094, 2005. [Journal]
14)  Dabrowski K, Terjesen BF, Zhang Y, Phang JM, Lee KJ.
A concept of dietary dipeptides: a step to resolve the problem of amino acid availability in the early life of vertebrates.
J Exp Biol. 208: 2885-94, 2005. [Journal]
15)  Liu Y, Borchert GL, Donald SP, Surazynski A, Hu CA, Weydert CJ, Oberley LW, Phang JM.
MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.
Carcinogenesis. 26: 1335-42, 2005. [Journal]
16)  Miltyk W, Surazynski A, Kasprzak KS, Fivash MJ, Buzard GS, Phang JM.
Inhibition of prolidase activity by nickel causes decreased growth of proline auxotrophic CHO cells.
J Cell Biochem. 94: 1210-7, 2005. [Journal]
17)  Hursting SD, Lavigne JA, Berrigan D, Donehower LA, Davis BJ, Phang JM, Barrett JC, Perkins SN.
Diet-gene interactions in p53-deficient mice: Insulin-like growth factor-1 as a mechanistic target.
J Nutr. 134: 2482S-2486S, 2004. [Journal]
18)  Salnikow K, Donald SP, Bruick RK, Zhitkovich A, Phang JM, Kasprzak KS.
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.
J Biol Chem. 24: 40337-44, 2004. [Journal]
19)  Liu Y, Borchert GL, Phang JM.
Polyoma enhancer activator 3, an Ets transcriptional factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells.
J Biol Chem. 279: 18694-700, 2004. [Journal]
20)  Phang JM. Goldman L, Ausiello D, eds.
The hyperprolinemias and hydroxyprolinemia. In: Cecil Textbook of Medicine. Volume 22nd edition.
Philadelphia: Saunders; 2004. p. 1285 [Book Chapter]
21)  Mei JM, Borchert GL, Donald SP, Phang JM.
Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex.
Carcinognesis. 23: 2119-2122, 2002. [Journal]
22)  Peng Y, Xu RH, Mei JM, Li XP, Yan D, Kung HF, Phang JM.
Neural inhibition by c-Jun as a synergizing factor in bone morphogenetic protein 4 signaling.
Neuroscience. 109: 657-64, 2002. [Journal]
23)  Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN.
Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis.
Mol Carcinog. 33: 16-24, 2002. [Journal]
24)  Donald SP, Sun XY, Hu CA, Yu J, Mei JM, Valle D, Phang JM.
Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.
Cancer Res. 61: 1810–5, 2001. [Journal]
25)  Sun XY, Donald SP, Phang JM.
Testosterone and prostate specific antigen stimulate generation of reactive.
Carcinogenesis. 22: 1775-80, 2001. [Journal]
26)  Phang JM. Creighton T, eds.
Prolidase. In: Encyclopedia of Molecular Medicine. Volume .
New York: John Wiley & Sons; 2001. p. 2585-9 [Book Chapter]
27)  Phang JM, Hu CA, Valle D. Scriver CR, Beaudet AL, Sly WS, Valle D, eds.
Disorders of proline and hydroxyproline metabolism. In: Metabolic and Molecular Basis of Inherited Disease. Volume 8th edition.
New York: McGraw-Hill; 2001. p. 1821-38 [Book Chapter]
28)  Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.
Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in.
FASEB J. 14: 1188-201, 2000. [Journal]
29)  Hursting SD, Perkins SN, Phang JM, Barrett JC.
Diet and cancer prevention studies in p53-deficient mice.
J. Nutr. 131: 3092S-4S, 2001. [Journal]
30)  Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.
Differential formation of beta-catenin/lymphoid enhancer factor-1 DNA binding complex induced by nitric oxide in mouse colonic epithelial cells differing in adenomatous polyposis coli (Apc) genotype.
Cancer Res. 60: 3379-83, 2000. [Journal]
31)  Mei JM, Hord NG, Winterstein DF, Donald SP, Phang JM.
Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated beta-catenin-LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc.
Carcinogenesis. 20: 737-40, 1999. [Journal]
32)  Hursting SD, Slaga TJ, Fischer SM, DiGiovanni J, Phang JM.
Mechanism-based cancer prevention approaches: targets, examples, and the use of transgenic mice.
J. Natl. Cancer Inst. 91: 215-25, 1999. [Journal]

This page was last updated on 9/24/2008.