Our Science – Yu Website

Yanlin Yu, Ph.D.

Laboratory of Cancer Biology and Genetics Staff Scientist National Cancer Institute Building 37, Room 5002 37 Convent Drive Bethesda, MD 20852 Phone:   301-402-4073 Fax:   Fax Number not listed E-Mail:   yy43g@nih.gov

Biography

Dr. Yanlin Yu graduated from Southern Medical University. He received an M.Sc degree in Genetics from Jinan University and a Ph.D. degree in Cell Biology from the Shanghai Institute of Cell Biology (currently named Shanghai Institute of Biochemistry and Cell Biology) in the Chinese Academy of Sciences. Dr. Yu was a faculty member at the Department of Cell Biology and Genetics in Southern Medical University. From 1998 to 2004, Dr. Yu worked at the Laboratory of Molecular Biology in the National Cancer Institute as a visiting fellow and research fellow. He currently works with Dr. Glenn Merlino in Laboratory of Cancer Biology and Genetics as a staff scientist. Dr. Yu won a NCI Director's Intramural Innovation Award in 2006.

Research

Dr. Yu's major research interest is focused on understanding molecular mechanisms in progression to the metastatic state in cancer. He has studied mechanisms underlying tumorigenesis in the hepatocellular carcinoma (HCC). Dr. Yu has generating transgenic mice inducibly expressing dominant negative fibroblast growth factor receptor (FGFR) mutants for studying the specific roles of receptor tyrosine kinases in cancer and normal development. He found that constitutive c-Met signaling through a non-autocrine mechanism promotes metastasis in a transgenic transplantation model, and determined that Ezrin and Six1 are critical regulators of metastasis in rhabdomyosarcoma.

This page was last updated on 7/15/2008.